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Drug Investigation

, Volume 6, Issue 2, pp 114–117 | Cite as

Colchicine Overdose in 6 Patients

Prospects for Prevention and Therapy
  • Alan Henderson
  • Bryan T. Ernmerson
  • Neville L. Bailey
  • Susan M. Pond
Case Reports

Summary

We report on 6 acute colchicine overdose patients, 4 of whom died. Five were young healthy adults who took tablets that belonged to someone else. Bacteraemia is not infrequent in such patients and it appears that broad spectrum antibiotic therapy should be introduced early in the course of the intoxication at the first signs of possible sepsis. Immunotherapy with colchicine-specific antibodies is a promising approach to treatment. An even better approach to the problem would be to prevent the poisoning in the first place by measures such as education and, perhaps, blister packaging the tablets.

Keywords

Colchicine Gout Acute Respiratory Distress Syndrome Activate Charcoal Saffron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1993

Authors and Affiliations

  • Alan Henderson
    • 1
  • Bryan T. Ernmerson
    • 1
  • Neville L. Bailey
    • 2
  • Susan M. Pond
    • 1
  1. 1.Department of Medicine and Intensive Care Unit, Princess Alexandra HospitalUniversity of QueenslandBrisbaneAustralia
  2. 2.Government Chemical LaboratoryQueensland HealthBrisbaneAustralia

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