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Drug Investigation

, Volume 4, Issue 3, pp 263–272 | Cite as

Long Term Efficacy and Safety of Carvedilol, a New β-Blocking Agent with Vasodilating Properties, in Patients with Chronic Ischaemic Heart Disease

  • P. DasGupta
  • D. Jain
  • A. Lahiri
  • E. B. Raftery
Original Research Article

Summary

The long term efficacy and safety of Carvedilol, a new vasodilating β-blocking drug, was evaluated in 32 patients with chronic stable angina, using a randomised double-blind, placebo-controlled protocol for 1 month, followed by an open phase of 5 months during which all patients received Carvedilol 25mg twice daily. Treadmill exercise testing was performed at the end of 1 (double-blind), 3 and 6 months (open phase). Five patients were withdrawn from the study, 2 because of adverse events and the rest because of noncompliance or surgical intervention during the study. Exercise time (mean ± SD) had improved significantly on Carvedilol at the end of the double-blind phase (1 month) from 6.6 ± 0.6 to 7.7 ± 0.7 min (p < 0.05) and this was maintained at 3 and 6 months (8.3 ± 0.7 min, p < 0.01 and 8.5 ± 0.7 min, p < 0.005, respectively). In the group started on placebo, exercise time also improved significantly from 6.4 ± 0.5 to 7.3 ± 0.5 min (p < 0.05), but this was further improved at 3 (8.0 ± 0.7 min) and 6 months (8.9 ± 0.8 min) with Carvedilol (p < 0.02 and p < 0.0001, respectively). Time to 1mm ST-segment depression did not alter significantly with placebo (4.8 ± 0.6 to 4.9 ± 0.4 min), but was significantly improved by Carvedilol at 1, 3 and 6 months (p < 0.05, p < 0.01 and p < 0.005, respectively). Similarly, time to development of angina during exercise did not alter with placebo (5.1 ± 0.4 to 5.4 ± 0.4 min), but was significantly increased by Carvedilol at 1 month (5.4 ± 0.4 to 6.3 ±0.6 min, p < 0.02), and this was maintained on long term therapy at 3 and 6 months (6.3 ±0.5 min, p < 0.005, and 6.9 ± 0.5 min, p < 0.001, respectively). Peak exercise heart rate and double product were reduced by active therapy only, at 1 month (124 ± 5 to 107 ± 3 beats/minute, p < 0.0001; 197 ± 11 to 160 ± 9, p < 0.0001), 3 months (108 ± 4, p < 0.0001; 162 ± 9, p < 0.001) and 6 months (108 ± 3, p < 0.0005; 157 ± 7, p < 0.0002), respectively. These results suggest that Carvedilol is a well tolerated and effective β-blocker; however, the lack of any significant difference in exercise time with placebo suggests that the dose of 25mg twice daily is insufficient in the management of chronic stable angina.

Keywords

Carvedilol Drug Invest Peak Exercise Exercise Time Chronic Stable Angina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • P. DasGupta
    • 1
  • D. Jain
    • 1
  • A. Lahiri
    • 1
  • E. B. Raftery
    • 1
  1. 1.Department of Cardiology and Division of Clinical SciencesNorthwick Park Hospital and Clinical Research CentreHarrowEngland

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