In Vitro Susceptibility of Bacteroides fragilis Group Strains from Abscesses, Body Fluids and Wound/Tissue Sources
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The in vitro activity of several antimicrobial agents was tested against over 1600 clinical isolates of the Bacteroides fragilis group obtained from abscesses, body fluids, and wound/tissue sources. Overall, isolates from body fluids tended to be slightly more resistant than those from abscesses or wounds/tissues. Regardless of isolate source, ceftizoxime was the most active cephalosporin tested, with resistance rates varying from 8 to 12%. Of the 3 cephamycin compounds tested, cefoxitin was considerably more active than cefotetan and cefmetazole against isolates from all 3 sources. Overall, the activities of piperacillin and mezlocillin were comparable, and each was superior to ticarcillin, with resistance rates of 7 to 12% vs 10 to 22%. Both carbapenems were highly active; however, imipenem was slightly more active than meropenem. The activity of clindamycin was similar against all 3 groups of isolates, with resistance rates of 10 to 11%. No isolates were resistant to metronidazole. B. fragilis species tended to be more susceptible to most antimicrobial agents compared with non-B. fragilis species. We conclude that species grouping is an important factor in susceptibility patterns of the B. fragilis group, whereas the source of isolates is relatively unimportant.
KeywordsClindamycin Imipenem Meropenem Resistance Rate Piperacillin
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