The Anti-Inflammatory, Analgesic and Antipyretic Activity of Nimesulide in Experimental Models
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Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) chemically different from other drugs of this class, is a 4-nitro-2-phenoxymethansulfonanilide, with a sulfonanilide as the acidic group. The anti-inflammatory activity of nimesulide has been demonstrated in a number of widely used experimental models of inflammation such as carrageenan-induced paw oedema in rats, Freund’s complete adjuvant-induced arthritis in rats, and UV-induced skin erythema in guineapigs.
The analgesic activity of nimesulide has been demonstrated in the Randall-Selitto test in rats and in the writhing test after intraperitoneal injection of phenylquinone in mice. Nimesulide also reduced the hyperthermia induced in rats by subcutaneous injection of yeast.
KeywordsPiroxicam Nimesulide Phenylbutazone Antipyretic Activity Pretreatment Interval
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