Summary
Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) chemically different from other drugs of this class, is a 4-nitro-2-phenoxymethansulfonanilide, with a sulfonanilide as the acidic group. The anti-inflammatory activity of nimesulide has been demonstrated in a number of widely used experimental models of inflammation such as carrageenan-induced paw oedema in rats, Freund’s complete adjuvant-induced arthritis in rats, and UV-induced skin erythema in guineapigs.
The analgesic activity of nimesulide has been demonstrated in the Randall-Selitto test in rats and in the writhing test after intraperitoneal injection of phenylquinone in mice. Nimesulide also reduced the hyperthermia induced in rats by subcutaneous injection of yeast.
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References
Böttcher I, Schweizer A, Glatt M, Werner H. A sulphonamidoindanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats. Drugs Under Experimental and Clinical Research 13: 237–245, 1987
Swingle KF, Grant TJ, Kvam DC. Quantal responses in the Randall-Selitto assay. Proceedings of the Society for Experimental Biology and Medicine 137: 536, 1971 Swingle KP, Moore GGI. Preclinical pharmacological studies with nimesulide. Drugs Under Experimental and Clinical Research 10: 587–597, 1984
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Velo, G.P. The Anti-Inflammatory, Analgesic and Antipyretic Activity of Nimesulide in Experimental Models. Drug Invest 3 (Suppl 2), 10–13 (1991). https://doi.org/10.1007/BF03258311
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DOI: https://doi.org/10.1007/BF03258311