Drug Investigation

, Volume 3, Supplement 2, pp 10–13 | Cite as

The Anti-Inflammatory, Analgesic and Antipyretic Activity of Nimesulide in Experimental Models

  • G. P. Velo


Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) chemically different from other drugs of this class, is a 4-nitro-2-phenoxymethansulfonanilide, with a sulfonanilide as the acidic group. The anti-inflammatory activity of nimesulide has been demonstrated in a number of widely used experimental models of inflammation such as carrageenan-induced paw oedema in rats, Freund’s complete adjuvant-induced arthritis in rats, and UV-induced skin erythema in guineapigs.

The analgesic activity of nimesulide has been demonstrated in the Randall-Selitto test in rats and in the writhing test after intraperitoneal injection of phenylquinone in mice. Nimesulide also reduced the hyperthermia induced in rats by subcutaneous injection of yeast.


Piroxicam Nimesulide Phenylbutazone Antipyretic Activity Pretreatment Interval 
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  1. Böttcher I, Schweizer A, Glatt M, Werner H. A sulphonamidoindanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats. Drugs Under Experimental and Clinical Research 13: 237–245, 1987PubMedGoogle Scholar
  2. Swingle KF, Grant TJ, Kvam DC. Quantal responses in the Randall-Selitto assay. Proceedings of the Society for Experimental Biology and Medicine 137: 536, 1971 Swingle KP, Moore GGI. Preclinical pharmacological studies with nimesulide. Drugs Under Experimental and Clinical Research 10: 587–597, 1984Google Scholar

Copyright information

© Adis International Limited 1991

Authors and Affiliations

  • G. P. Velo
    • 1
  1. 1.Institute of PharmacologyUniversity of VeronaVeronaItaly

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