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Pharmaceutical & Diagnostic Innovation

, Volume 2, Issue 2, pp 22–25 | Cite as

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Progress Report for HIV Entry Inhibitors from the 11th CROI Meeting
Emerging Technology
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Despite advances in the development of potent antiretroviral regimens that block HIV transcription and assembly, problems of drug resistance, latent viral reservoirs and drug-induced toxic effects that compromise effective viral control all point to the need for new classes of anti-HIV drugs with different modes of action. One promising approach involves blocking HIV entry into cells.

The process of HIV entry begins with binding of the viral envelope glycoprotein to both the CD4 receptor and one of only two chemokine receptors, and ends with fusion of viral and cell membranes. Viral entry provides novel therapeutic targets against HIV. To date, at least 3 sub-classes of HIV viral entry/fusion inhibitors have emerged:

  • CD4 binding or attachment — targets initial recognition and binding of the viral glycoprotein gp120 to the cell-surface CD4 antigen.

  • Chemokine co-receptor binding — targets binding of virus to the CCR5 or CXCR4 co-receptor.

  • Fusion inhibition — targets the viral...

Keywords

Viral Load Enfuvirtide CCR5 Antagonist Entry Inhibitor Optimize Background Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    11th Conference on Retroviruses and Opportunistic Infections (2004); abstr. 536Google Scholar
  2. 2.
    11th Conference on Retroviruses and Opportunistic Infections (2004); abstr. 141Google Scholar
  3. 3.
    11th Conference on Retroviruses and Opportunistic Infections (2004); abstr. 140LBGoogle Scholar

Copyright information

© Adis Data Information BV 2004

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