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Seeking alternatives to PSA testing
Biomarker panel for diagnosing prostate cancer
Researchers at the University of Michigan Comprehensive Cancer Center have identified a panel of 22 biomarkers that together provide a more accurate screening for prostate cancer than the current prostate-specific antigen (PSA) test. “Initially, we envision this new test could be used as a supplement to PSA. A physician might suggest a patient with an elevated PSA have this test before a biopsy to better determine whether it’s a cancerous or benign condition. In the future, I think this could replace PSA,” commented lead author Professor Arul Chinnaiyan.
The researchers tested blood serum samples from 39 men with prostate cancer and 21 controls to identify autoantibodies against prostate cancer. They scanned 2300 autoantibodies and initially narrowed it down to 186 that reacted with blood serum from men with prostate cancer. This discovery phase formed the basis for the next round of tests, in which...
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