Rapid Relief of Rhinitis with R112
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Allergic rhinitis is a chronic inflammatory disorder caused by ‘overreaction’ of an individual’s immune system to an environmental substance (allergen). The four main symptoms are sneezing, nasal congestion, rhinorrhea (runny nose) and itching in the eyes, ears, nose and throat, reflecting the underlying inflammation of mucosal surfaces. Affecting around 20% of the US population, allergic rhinitis has a significant negative effect on patient quality of life and is associated with an annual economic burden of approximately $US5.3 billion. Although a range of pharmacological therapies is available for allergic rhinitis, intranasal corticosteroids and oral antihistamines dominate the market.
A major unmet need in allergic rhinitis therapy is management of patients unable to achieve adequate control of symptoms with available drugs. Therefore, interest is growing in therapies with novel mechanisms of action. One such candidate is R112 from Rigel Pharmaceuticals, a...