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Pharmaceutical Medicine

, Volume 26, Issue 1, pp 45–47 | Cite as

Phase III ATENA Trial of Exemestane Discontinued

  • Mel Sweetlove
Trial Report
  • 34 Downloads

Abstract

ATENA (Adjuvant post-Tamoxifen Exemestane versus Nothing Applied): a phase III randomized parallel-group multicenter trial, designed to compare 5 Years of adjuvant exemestane versus 5 years of observation in postmenopausal women with operable breast cancer who have received 5–7 years of adjuvant tamoxifen. The primary endpoint is disease-free survival. The effects of extended adjuvant therapy with exemestane on the lipid profile was a secondary endpoint. This trial was prematurely discontinued in November 2005 due to poor accrual following publication of the results of the MA.17 trial, which demonstrated a reduced risk of recurrence with extended adjuvant therapy using letrozole.

Keywords

Tamoxifen Postmenopausal Woman Adjuvant Therapy Letrozole Exemestane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Adis Data Information BV 2012

Authors and Affiliations

  • Mel Sweetlove
    • 1
  1. 1.AdisAucklandNew Zealand

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