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Molecular Diagnosis & Therapy

, Volume 16, Issue 2, pp 63–77 | Cite as

Molecular Diagnosis and Management of Viral Infections in Hematopoietic Stem Cell Transplant Recipients

  • Sabine Breuer
  • Margit Rauch
  • Susanne Matthes-Martin
  • Thomas Lion
Review Article

Abstract

Viral infections after allogeneic hematopoietic stem cell transplantation (HSCT) are important complications associated with high morbidity and mortality. In this setting, reactivations of persisting latent viral pathogens from donor and/or recipient cells play a central role whereas the sterile environment of transplant units renders new infections less likely. The viruses currently regarded as most relevant in the HSCT setting include particularly the herpes virus family—specifically cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6) —as well as human adenoviruses (AdVs) and the polyoma virus BK (BKV). Timely detection and monitoring of virus copy numbers are prerequisites for successful preemptive treatment approaches. Pre- and post-transplant surveillance by sensitive and quantitative molecular methods has therefore become an essential part of the diagnostic routine. In this review, we discuss diagnostic aspects and the clinical management of the most important viral infections in HSCT recipients, with a focus on pediatric patients.

Keywords

Hematopoietic Stem Cell Transplantation Ganciclovir Varicella Zoster Virus Allogeneic Hematopoietic Stem Cell Transplantation Cidofovir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Sabine Breuer and Margit Rauch contributed equally to the manuscript. There was no funding provided for preparation of the paper. The authors declare no conflicts of interest.

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Copyright information

© Adis Data Information BV 2012

Authors and Affiliations

  • Sabine Breuer
    • 1
  • Margit Rauch
    • 2
  • Susanne Matthes-Martin
    • 1
  • Thomas Lion
    • 2
  1. 1.Department of Pediatric Stem Cell TransplantationSt. Anna Children’s Hospital, Medical University of ViennaViennaAustria
  2. 2.Children’s Cancer Research InstituteMedical University of ViennaViennaAustria

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