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Adverse Drug Reactions and Toxicological Reviews

, Volume 21, Issue 4, pp 253–260 | Cite as

Adverse Drug Reaction Update

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Increasing numbers of articles on adverse drug reactions are published in a wide range of medical journals. To help keep you up-to-date with the latest advances worldwide on all aspects of adverse drug reactions, this section of the journal brings you information selected from the drug safety alerting service Reactions Weekly1. The following reports are selected from the latest issues, summarizing the most important clinical studies, adverse reaction news, and expert opinion pieces published across a broad range of literature sources.

‘Zyban’ Safety Update from the UK Medicines Control Agency

The UK Medicines Control Agency (MCA) has issued a new safety update for ‘Zyban’ (bupropion) that includes a reminder to prescribers that ‘Zyban’ is contraindicated in patients with current or previous seizure disorders.

Up to 24 July 2002 the UK MCA had received a total of 7630 reports of suspected adverse reactions associated with ‘Zyban’ via the Yellow Card Scheme. However, it is noted that a...

Reference

  1. Medicines Control Agency. Zyban (bupropion hydrochloride) — safety update. Internet document: [1 page]. Available from: URL: http://www.mca.gov.uk [Accessed 2002 Jul 29]

Reference

  1. Shaffer D, Singer S, Korvick J, et al. Concomitant risk factors in reports of Torsades de pointes associated with macrolide use: review of the United States Food and Drug Administration Adverse Event Reporting System. Clin Infect Dis 2002; 35: 197–200PubMedCrossRefGoogle Scholar

Reference

  1. Nousiainen T, Jantunen E, Vanninen E, et al. Early decline in left ventricular ejection fraction predicts doxorubicin cardiotoxicity in lymphoma patients. Br J Cancer 2002; 86(11): 1697–700PubMedCrossRefGoogle Scholar

Reference

  1. Koro CE, Fedder DO, L’Italien GJ, et al. Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study. BMJ 2002; 325: 243–5PubMedCrossRefGoogle Scholar

Reference

  1. Verster JC, Volkerts ER, Verbaten MN. Effects of alprazolam on driving ability, memory functioning and psychomotor performance: a randomized, placebo-controlled study. Neuropsychopharmacology 2002; 27: 260–9PubMedCrossRefGoogle Scholar

Reference

  1. Lacey Jr JV, Mink PJ, Lubin JH, et al. Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA 2002; 288: 334–41PubMedCrossRefGoogle Scholar

Reference

  1. Meinardi MT, van der Graaf WTA, Gietema JA, et al. Evaluation of long term cardiotoxicity after epirubicin containing adjuvant chemotherapy and locoregional radiotherapy for breast cancer using various detection techniques. Heart 2002; 88: 81–2PubMedCrossRefGoogle Scholar

Reference

  1. World Health Organization. Kava-Kava and Kavaine containing products withdrawn in Germany due to hepatotoxic risks. Internet document: [1 page]. Available from URL: http://www.who.int/medicines [Accessed 2002 Jun 17]

Reference

  1. Reilly JG, Ayis SA, Ferrier IN, et al. Thioridazine and sudden unexplained death in psychiatric in-patients. Br J Psychiatry 2002 Jun; 180: 515–22PubMedCrossRefGoogle Scholar

References

  1. 1.
    Livre M. Alosetron for irritable bowel syndrome. BMJ 2002; 325: 555–6CrossRefGoogle Scholar
  2. 2.
    Moynihan R. FDA advisers warn of more deaths if drug is relaunched. BMJ 2002; 325: 561PubMedCrossRefGoogle Scholar
  3. 3.
    Moynihan R. Alosetron: a case study in regulatory capture, or a victory for patients’ rights? BMJ 2002; 325: 592–5PubMedCrossRefGoogle Scholar

Reference

  1. Sorensen MB, Collins P, Ong PJL, et al. Long-term use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance. Circulation 2002; 106: 1646–51PubMedCrossRefGoogle Scholar

Reference

  1. Vanhatalo S, Nousiainen I, Eriksson K, et al. Visual field constriction in 91 Finnish children treated with vigabatrin. Epilepsia 2002; 43: 748–56PubMedCrossRefGoogle Scholar

Reference

  1. Destefano F, Gu D, Kramarz P, et al. Childhood vaccinations and risk of asthma. Pediatr Infect Dis J 2002; 21: 498–504PubMedCrossRefGoogle Scholar

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© Adis International Limited 2002

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