Short-term cost and health consequences of duodenal levodopa infusion in advanced Parkinson’s disease in Sweden
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Levodopa is the cornerstone treatment for Parkinson’s disease, but the short half-life of levodopa limits its usefulness in late stages of the disease. Duodenal levodopa infusion (DLI) allows more stable plasma levels and better motor symptom control.
To explore the costs and health benefits of replacing conventional oral polypharmacy with DLI in patients with advanced Parkinson’s disease, from a Swedish healthcare payer perspective.
Based on a clinical, randomized, crossover study with 24 patients (DIREQT), a decision analytic model predicted 2-year drug costs and QALYs for conventional oral therapy and for DLI. Health-related quality of life (HR-QOL) was recorded using a 15-dimensional (15D) utility instrument at baseline and during the two 3-week trial periods, and then at eight follow-up visits during the subsequent 6 months. Use of medication was based on data from DIREQT and previous studies. Unit costs were based on market prices (drugs) and customary charges in Sweden. All costs were expressed in Swedish kronor (SEK), year 2004 values (€1.00 ≈ SEK9.17, $US1.00 = SEK7.47). Future costs and outcomes were discounted at 3%. One-way and probabilistic sensitivity analyses were conducted.
The mean utility scores were 0.77 for DLI and 0.72 for conventional therapy (p = 0.02). A considerable variation in the scores was observed during the study. The expected per-patient 2-year cost of DLI was SEK562000 while it was SEK172 000 for conventional therapy. The mean number of QALYs was 1.48 and 1.42, respectively, representing an incremental cost of SEK6.1 million per QALY for DLI (all values discounted at 3%). Using other assumptions in sensitivity analyses, the cost per QALY could be as low as SEK456000.
This analysis can be considered exploratory only; it is based on very limited data. Nevertheless, our findings suggest that DLI results in a significant improvement in HR-QOL. However, the cost per QALY is likely to be higher than customary cost-effectiveness thresholds. Whether these benefits justify the additional costs depends on how the health benefits are measured and how these benefits are valued by society.
KeywordsLevodopa Deep Brain Stimulation Conventional Therapy Percutaneous Endoscopic Gastrostomy Orphan Drug
This study was initiated and funded by Neopharma/Solvay. According to the contract between the researchers and the company, the former have the right to publish material from the study, but the company has the right to comment upon such material before it is published. All researchers had access to the full data file, and the analyses were undertaken by the researchers. D. Nyholm was employed by NeoPharma in 1999–2000, has an ongoing consultancy agreement with Solvay Pharma and has received honoraria from Neopharma/ Solvay for lectures and a book chapter. I. Kristiansen, D. Isacson and K. Bingefors received honoraria for this work.
- 4.Lees AJ. The on-off phenomenon. J Neurol Neurosurg Psychiatry 1989 Jun; Suppl.: 29–37Google Scholar
- 24.Sintonen H. The 15D-measure of health related quality of life: II. Feasibility, reliability and validity of its valuation system. Melbourne (VIC): National Centre for Health Program Evaluation, 1995Google Scholar
- 25.Wittrup-Jensen KU. Measurement and valuation of health-related quality of life [dissertation]. Odense: University of Southern Denmark, 2004Google Scholar
- 26.Nord E. Cost-value analysis in health care. Cambridge: Cambridge University Press, 1999Google Scholar
- 30.Continuous delivery of levodopa/carbidopa in patients with advanced Parkinson’s disease compared to conventional medications [report]. Uppsala: Neopharma, 2004 Nov 7. (Data on file)Google Scholar
- 31.Nyholm D, Lewander T. A retrospective study of patients treated with Duodopa/Duodopa N from January 1, 1991 to June 30, 2002 [report]. Uppsala: Neopharma, 2003 Aug 8. (Data on file)Google Scholar
- 32.Jonsson L, Gurner L. Vad kostar vård och omsorg av aldre multisjuka? Rapport 2001: 7. Stockholm: lans Aldrecentrum, 2004Google Scholar
- 34.Nordling S, Grabowski M, Hagell P, et al. Societal costs of Parkinson’s disease (in Swedish) [report]. IHE Arbetsrapport 2001: 2. Lund: Institute for Health Economics, 2001Google Scholar
- 56.World Health Organization. Bulletin of the World Health Organization (BLT) [online]. Available from URL: http://www.who.int/bulletin/archives/78(2)274.pdf [Accessed 2009 Sep 8]