Cytotoxic and antimicrobial properties of furoflavones and furochalcones

Bioactive Materials Article


Antibacterial, antifungal, and cytotoxic activities of synthetic but naturally abundant furoflavones were evaluated, including pongaglabrone (1), pongaglabol methyl ether (2), lanceolatin B (3), pongaglabol (4), and their corresponding furochalcones (5-8) against selected bacterial and fungal strains and brine shrimp (Artemia salina) nauplii, respectively. Among the tested compounds, pongaglabrone (1) showed strong inhibition of bacterial growth against Shigella dysenteriae and Streptococcus β-haemolyticus. All furoflavones exhibited significant antibacterial activity against S. dysenteriae, Salmonella typhi, Streptococcus-β-haemolyticus, and Staphylococcus aureus, whereas the furochalcones showed selective antibacterial activity. Compound 2 exhibited the highest antifungal activity, followed by compound 1, against Aspergillus niger and Aspergillus fumigatus. Among the furochalcones tested, only compound 6 showed antifungal activity. Cytotoxicities of the synthesized compounds were compared in a short term bioassay using A. Salina. Among the substances tested, compound 1 showed the highest cytotoxicity, followed by 2, 4, and 3, with LC50 values of 5.46, 8.53, 9.08, and 14.67 ppm, respectively.


antibacterial antifungal brine shrimp toxicity furochalcones furoflavones 


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Copyright information

© Korean Society for Applied Biological Chemistry and Springer 2011

Authors and Affiliations

  1. 1.Division of BioscienceDongguk UniversityGyeongjuRepublic of Korea
  2. 2.Department of ChemistryJagannath UniversityDhakaBangladesh

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