Cytotoxic and antimicrobial properties of furoflavones and furochalcones

  • Mohammad Sayed Alam
  • Dong-Ung Lee
Bioactive Materials Article


Antibacterial, antifungal, and cytotoxic activities of synthetic but naturally abundant furoflavones were evaluated, including pongaglabrone (1), pongaglabol methyl ether (2), lanceolatin B (3), pongaglabol (4), and their corresponding furochalcones (5-8) against selected bacterial and fungal strains and brine shrimp (Artemia salina) nauplii, respectively. Among the tested compounds, pongaglabrone (1) showed strong inhibition of bacterial growth against Shigella dysenteriae and Streptococcus β-haemolyticus. All furoflavones exhibited significant antibacterial activity against S. dysenteriae, Salmonella typhi, Streptococcus-β-haemolyticus, and Staphylococcus aureus, whereas the furochalcones showed selective antibacterial activity. Compound 2 exhibited the highest antifungal activity, followed by compound 1, against Aspergillus niger and Aspergillus fumigatus. Among the furochalcones tested, only compound 6 showed antifungal activity. Cytotoxicities of the synthesized compounds were compared in a short term bioassay using A. Salina. Among the substances tested, compound 1 showed the highest cytotoxicity, followed by 2, 4, and 3, with LC50 values of 5.46, 8.53, 9.08, and 14.67 ppm, respectively.


antibacterial antifungal brine shrimp toxicity furochalcones furoflavones 


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Copyright information

© Korean Society for Applied Biological Chemistry and Springer 2011

Authors and Affiliations

  1. 1.Division of BioscienceDongguk UniversityGyeongjuRepublic of Korea
  2. 2.Department of ChemistryJagannath UniversityDhakaBangladesh

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