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Comparison of techniques for the extraction of the hypotensive drugs geniposidic acid and geniposide from Eucommia ulmoides

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Abstract

The extraction of geniposidic acid and geniposide from Eucommia ulmoides was carried out by Soxhlet extraction, enzyme-assisted aqueous extraction, semi-bionic extraction and supercritical fluid extraction techniques and the extracts were analyzed by high performance liquid chromatography. The results showed that the best methods for extraction of geniposidic acid and geniposide are enzyme-assisted aqueous extraction and semi-bionic extraction. Compared with various extraction methods, the semi-bionic extraction was more efficient, yielding the highest amount of geniposidic acid and geniposide. In semi-bionic extraction, no organic solvent was used. Semi-bionic extraction was performed at the same pH as that of the human body. The results indicated that semi-bionic extraction was the best method for large-scale efficient extraction of geniposidic acid and geniposide from plant materials. The supercritical fluid extraction process required more time than the other methods, and gave the lowest yields of geniposidic acid and geniposide.

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References

  1. R.H. Huang, Y. Xiang, X.Z. Liu, Y. Zhang, Z. Hu, D.C. Wang, FEBS Lett. 521 (2002) 87.

    CAS  Google Scholar 

  2. T. Deyama, S. Nishibe, Y. Nakazawa, Acta Pharmacol. Sin. 22 (2001) 1057.

    Google Scholar 

  3. H.Y. Cheung, W.P. Lai, M.S. Cheung, F.M. Leung, D.J. Hood, W.F. Fong, J. Chromatogr. A. 989 (2003) 303.

    CAS  Google Scholar 

  4. T. Deyama, T. Ikawa, S. Kitagawa, S. Nishibe, Chem. Pharm. Bull. 34 (1986) 4933.

    CAS  Google Scholar 

  5. T. Deyama, T. Ikawa, S. Kitagawa, S. Nishibe, Chem. Pharm. Bull. 34 (1986) 523.

    CAS  Google Scholar 

  6. T. Deyama, T. Ikawa, S. Nishibe. Chem. Pharm. Bull. 33 (1985) 3651.

    CAS  Google Scholar 

  7. T. Deyama, T. Ikawa, S. Kitagawa, S. Nishibe, Chem. Pharm. Bull. 35 (1987) 1803.

    CAS  Google Scholar 

  8. T. Deyama. Chem. Pharm. Bull. 31 (1983) 2993.

    CAS  Google Scholar 

  9. T. Deyama, T. Ikawa, S. Kitagawa, S. Nishibe, Chem. Pharm. Bull. 34 (1986) 523.

    CAS  Google Scholar 

  10. T. Deyama, T. Ikawa, S. Kitagawa, S. Nishibe, Chem. Pharm. Bull. 35 (1987) 1785.

    CAS  Google Scholar 

  11. Y. Li, T. Sato, K. Metori, K. Koike, Q. Che, M. Takahashi, Biol. Pharm. Bull. 21 (1998) 1306.

    CAS  Google Scholar 

  12. M. Nishizawa, R. Izuhara, K. Ksnrko, Y. Koshihara, Y. Fujimoto, Chem. Pharm. Bull. 36 (1988) 87.

    CAS  Google Scholar 

  13. S. Ueda, Y. Iwahashi, H.J. Tokuda, Nat. Prod. 54 (1991) 1677.

    CAS  Google Scholar 

  14. M. Lee, J. Hsu, C. Wang, Anticancer Res. 15 (1995) 411.

    CAS  Google Scholar 

  15. J. Kang, H.W. Wang, T.Y. Liu, Y.C. Chen, T.H. Ueng, Food Chem. Toxicol. 35 (1997) 957.

    CAS  Google Scholar 

  16. T. Nakamura, Y. Nakazawa, S. Onizuka, S. Satoh, A. Chiba, K. Sekihashi. Mutat. Res. 388 (1997) 7.

    CAS  Google Scholar 

  17. G.C. Yen, C.L. Hsieh, J. Agric. Food Chem. 48 (2000) 3431.

    CAS  Google Scholar 

  18. M.K. Lee, M.J. Kim, S.Y. Cho, S.A. Park, K.K. Park, U.J. Jung, H.M. Park, M.S. Choi, Diabetes Res. Clin. Pr. 67 (2005) 22.

    Google Scholar 

  19. G.W. Lee, H.C. Yoon, S.Y. Byun, Enzyme Microb. Tech. 35 (2004) 632.

    CAS  Google Scholar 

  20. G.C. Yen, C.L. Hsieh, Food Chem. 77 (2002) 449.

    CAS  Google Scholar 

  21. H. Cao, J.B. Xiao, M. Xu, J. Food Compos. Anal. 20 (2007) 45.

    CAS  Google Scholar 

  22. R.M. Smith, M.D. Burford, J. Chromatogr. 627 (1992) 255.

    CAS  Google Scholar 

  23. D.Q. Huo, J. Liu, W. Zhang, Chin. Trad. Patent Med. 26 (2004) 96.

    Google Scholar 

  24. X.L. Zhang, Z.W. Zhang, C.Q. Liu, Chin.Trad. Patent Med. 24 (2002) 575.

    CAS  Google Scholar 

  25. P. Hanmoungjai, D.L. Pyle, K. Niranjan, J. Chem. Techn. Biotech. 77 (2002) 771.

    CAS  Google Scholar 

  26. T. Puangsri, S.M. Abdulkarim, H.M. Ghazali, J. Food Lipids 12 (2005) 62.

    CAS  Google Scholar 

  27. S. Aparna, S.K. Khare, M.N. Gupta, J. Am. Oil Chem. Soc. 79 (2002) 215.

    Google Scholar 

  28. J. Buchert, J.M. Koponen, M. Suutarinen, A. Mustranta, M. Lille, R. Törrönen, K. Poutanen, J. Sci. Food Agric. 85 (2005) 2548.

    CAS  Google Scholar 

  29. A.K. Landbo, A.S. Meyer, J. Agric. Food Chem. 49 (2001) 169.

    Google Scholar 

  30. H. Li, B. Chen, Z.H. Zhang, Talanta 63 (2004) 659.

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China

    S. D. Wu, X. Y. Jiang, Q. Y. Chen & X. Q. Chen

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  1. S. D. Wu
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  2. X. Y. Jiang
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  3. Q. Y. Chen
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Correspondence to X. Q. Chen.

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Wu, S.D., Jiang, X.Y., Chen, Q.Y. et al. Comparison of techniques for the extraction of the hypotensive drugs geniposidic acid and geniposide from Eucommia ulmoides . JICS 4, 205–214 (2007). https://doi.org/10.1007/BF03245968

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  • DOI: https://doi.org/10.1007/BF03245968

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