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Journal of the Iranian Chemical Society

, Volume 4, Issue 2, pp 205–214 | Cite as

Comparison of techniques for the extraction of the hypotensive drugs geniposidic acid and geniposide from Eucommia ulmoides

  • S. D. Wu
  • X. Y. Jiang
  • Q. Y. Chen
  • X. Q. Chen
Article

Abstract

The extraction of geniposidic acid and geniposide from Eucommia ulmoides was carried out by Soxhlet extraction, enzyme-assisted aqueous extraction, semi-bionic extraction and supercritical fluid extraction techniques and the extracts were analyzed by high performance liquid chromatography. The results showed that the best methods for extraction of geniposidic acid and geniposide are enzyme-assisted aqueous extraction and semi-bionic extraction. Compared with various extraction methods, the semi-bionic extraction was more efficient, yielding the highest amount of geniposidic acid and geniposide. In semi-bionic extraction, no organic solvent was used. Semi-bionic extraction was performed at the same pH as that of the human body. The results indicated that semi-bionic extraction was the best method for large-scale efficient extraction of geniposidic acid and geniposide from plant materials. The supercritical fluid extraction process required more time than the other methods, and gave the lowest yields of geniposidic acid and geniposide.

Keywords

Geniposidic acid and Geniposide Eucommia ulmoides Enzyme-assisted aqueous extraction Supercritical fluid extraction Soxhlet extraction Semi-bionic extraction 

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Copyright information

© Iranian Chemical Society 2007

Authors and Affiliations

  • S. D. Wu
    • 1
  • X. Y. Jiang
    • 1
  • Q. Y. Chen
    • 1
  • X. Q. Chen
    • 1
  1. 1.College of Chemistry and Chemical EngineeringCentral South UniversityChangshaPR China

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