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Journal of the Iranian Chemical Society

, Volume 8, Issue 3, pp 687–693 | Cite as

A novel PVC membrane sensor for determination of loratadine in pharmaceutical compounds and blood serum

  • M. H. Mashhadizadeh
  • A. Hadjiakhoondi
  • S. Ahmadaghaei
Article

Abstract

A novel PVC membrane-selective electrode based on loratadine-tetraphenyl borate ion-pair was prepared for the determination of loratadine potentiometrically. This electrode exhibits a Nernstian slope of 59.1 ± 0.3 mV decade-1 for loratadine in a concentration range of 5.0 × 10-6−1.0 × 10-2 M at pH 2.2 with a detection limit of 2.9 × 10-6 M. The potential of the electrode is very stable and exhibits good reproducibility with very fast response time (∼3 s). The selectivity of the proposed electrode towards some cations and organic compounds was tested and the selectivity coefficients were calculated. The electrode was successfully applied to the determination of loratadine in tablets and blood samples.

Keywords

Loratadine Potentiometric sensor PVC membrane electrode Tetraphenyl borate Pharmaceutical compound 

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Copyright information

© Iranian Chemical Society 2011

Authors and Affiliations

  • M. H. Mashhadizadeh
    • 1
  • A. Hadjiakhoondi
    • 2
  • S. Ahmadaghaei
    • 1
  1. 1.Faculty of ChemistryTarbiat Moallem UniversityTehranIran
  2. 2.Faculty of Pharmacy and Medicinal Plants Research CenterTehran Medical Science UniversityTehranIran

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