, Volume 9, Issue 1, pp 7–16 | Cite as

Lactic acid and lactates

In health and wellness
  • Victor V.A.M. Schreurs
  • Gertjan Schaafsma


This review aims to integrate the present state of knowledge on lactate metabolism in human and mammalian physiology as far as it could be subject to nutritional interventions. An integrated view on the nutritional, metabolic and physiological aspects of lactic acid and lactates might open a perspective for innovative nutritional applications of lactates in health and wellness.

Lactic acid was classically considered to be a dead end waste product of anaerobic glycolysis during severe exercise. Mammals, however, do not excrete lactate indicating that lactate cannot be considered as a dead metabolic end product. Despite a rapid and massive production of lactate, lactate is finally oxidized to the normal metabolic end products CO2 and H2O. Besides direct metabolic effects, nutritional applications of lactic acid and lactates are also considered in relation to dietary mineral supply. To the background that lactic acid is in fact a semi manufactured metabolic product, various nutritional applications are proposed in relation to metabolic training of athletes, modulation of metabolic rate, appetite control and excretion of faecal fat for weight management, lowering the glycemic index of bread and improved mineral supplementation in nutritional formulas for infants and people using proton inhibitors.

Key words

Metabolism Nutrition Training Energy ATP production Anaerobic 


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  1. 1.
    Gladden LD (2008) 200th Anniversary of lactate research in muscle Exercise & Sport Sci Rev 36(3) 109–115Google Scholar
  2. 2.
    Gladden LD (2004) Lactate metabolism: a new paradigm for the third millennium J Physiol 558 5–30Google Scholar
  3. 3.
    Allen DG, Westerblad H (2004) Lactic acid, the latest performance enhancing drug Science 303 1112–1113Google Scholar
  4. 4.
    DiGirolamo M, Newby DF, Lovejoy J (1992) Lactate production in adipose tissue, a regulated function with extra-adipose implications Faseb J 6 2405–2412Google Scholar
  5. 5.
    Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate and insulin for 24 h in patients with NIDDM Diabetes 37 1020–1024Google Scholar
  6. 6.
    Woerle HJ, Meyer Ch, Dostou JM, Gosmanov NR, Islam N, Popa E, Wittlin SD, Welle SL, Gerich JE (2003) Pathways for glucose disposal after meal ingestion in humans. American Journal of Physiology Endocrinol Metab 284 E716–E725Google Scholar
  7. 7.
    Schreurs VVAM, Aarts M, IJssennagger N, Hermans J, Hendriks WH (2007) Energetic and metabolic consequences of aerobic and an-aerobic ATP-production Eur J Nutraceut & Funct Foods 18 (5) 25–28Google Scholar
  8. 8.
    Bender DA (2008) Introduction to nutrition and metabolism, 4th edition Taylor and Francis Group, London, UK ISBN 1-4200-4312-9Google Scholar
  9. 9.
    Frayn KN (2003) Metabolic regulation, a human perspective 2nd edition Blackwell Publishing Company, Oxford, UK. ISBN 0-632-06384-XGoogle Scholar
  10. 10.
    McArdle WD, Katch FI, Katch VL (2007) Exercise physiology: energy, nutrition and human performance 6th edition. Lippincott Williams & Wilkins, Baltimore, USA ISBN 0-7817-4990-5Google Scholar
  11. 11.
    Robergs RA, Ghisvand F, Parker D (2004) Biochemistry of exercise induced acidosis Am J Physiol Regul Integr Comp Physiol 287 502–516Google Scholar
  12. 12.
    Philp A, MacDonald AL, Watt PW (2005) Lactate, a signal coordinating cell and systemic function J Exp Biol 208 4561–4575Google Scholar
  13. 13.
    Dubouchaud H, Butterfield GE, Wolfel E, Bergman C, Brooks GA (2000) Endurance training expression and physiology of LDH, MCT-1 and MCT-4 in human skeletal muscle Am J Physiol Endocrinol Metab 278 571–579Google Scholar
  14. 14.
    Juel C, Holten MK, Dela F (2004) Effects of strength training on muscle lactate release and MCT-1 and MCT-4 content in healthy and type 2 diabetic humans J Physiol 556(1) 297–304Google Scholar
  15. 15.
    Schreurs VVAM, Nolles JA, Krawielitzki K, Bujko J (2007) Mathematical analysis of human [13CO2]-breath test results: post prandial fate of amino acids is related to their dietary form Eur Ass Animal Production 124 237–238Google Scholar
  16. 16.
    Brooks GA (2007) Lactate, link between glycolytic and oxidative metabolism Sports Med 37 341–343Google Scholar
  17. 17.
    Sepponen K, Ruusunen M, Pakkanen JA, Pösö AR (2007) Expression of CD 147 and monocarboxylate transporters MCT-1, MCT-2 and MCT-4 in porcine small intestine and colon Vet J 174 122–128Google Scholar
  18. 18.
    Bergersen LH (2007) Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle Neurosci 145 11–19.Google Scholar
  19. 19.
    Hashimoto T, Brooks GA (2008) Mitochondrial lactate oxidation complex and an adaptive role for lactate production Med Sci Sports Exercise 40(3) 486–494Google Scholar
  20. 20.
    Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation Biomed J 343 281–299Google Scholar
  21. 21.
    Connor H, Woods HF (1982) Quantitative aspects of L(+) lactate metabolism in human beings Metabolic acidosis Pitman Books Ltd, London, UK. 214–234Google Scholar
  22. 22.
    Wasserman DH, Conolly CC, Pagliassotti MJ (1991) Regulation of hepatic lactate balance during exercise Med Sci Sports Exercise 23 912–929Google Scholar
  23. 23.
    Liu SQ (2003) Practical implications of lactate and pyruvate metabolism by lactic acid bacteria in food and beverage fermentation Int J Food Microbiol 83 115–131Google Scholar
  24. 24.
    Bakker GCM (2005) Lactate in relation to human physiology; an overview TNO Report V6335 TNO Physiological Sciences Zeist, the NetherlandsGoogle Scholar
  25. 25.
    Bongaerts G, Bakkeren J, Severijnen R, Sperl W, Willems H, Naber T, Wevers R, van Meurs A, Tolboom J (2000) Lactobacilli and acidosis in children with short small bowel J Ped Gastroenterol Nutr 30 288–293Google Scholar
  26. 26.
    Iwanaga T, Takebe K, Kato I, Karaki S, Kuwahara A (2006) Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of mouse, rat and humans, with special reference to sic5a8 Biomed Res 27 243–254Google Scholar
  27. 27.
    Rizhaupt A, Wood IS, Ellis A, Hosie KB et al (1998) Identification and characterization of a monocarboxylate transporter (MCT-1) in pig and human colon: its potential to transport L-lactate as well as butyrate J Physiol 513(3) 719–732Google Scholar
  28. 28.
    Starkie RL, Hargreaves M, Lambert DL, Proietto J, Febbraio MA (1999) Effect of temperature on muscle metabolism during sub maximal exercise in humans Exp Physiol 84 775–784Google Scholar
  29. 29.
    Hettinga FJ, de Koning JJ, de Vrijer A, Wüst RCI et al (2007) The effect of ambient temperature on gross-efficiency in cycling Eur J Appl Physiol 101(4) 465–471Google Scholar
  30. 30.
    Schurr A (2006) Lactate: the ultimate cerebral oxidative energy substrate? J Cer Blood Flow Metab 26 142–152Google Scholar
  31. 31.
    Brooks GA (2002) Lactate shuttles in nature Biomed Soc Trans 30 258–264Google Scholar
  32. 32.
    Brooks GA (2007) Body — mind learning: a lesson for the mind from muscle Exercise Sports Sci Rev 35 (4) 163–165Google Scholar
  33. 33.
    Gladden LD (2008) A ‚Lactatic’ perspective on metabolism Med Sci Sports Exercise 40(3) 477–485Google Scholar
  34. 34.
    Hertz L and Dienel GA (2005) Lactate transport and transporters: General principles and functional roles in brain cells J Neurosci Res 79(1) 11–18Google Scholar
  35. 35.
    Leverve X (1998) Metabolic and nutritional consequences of chronic hypoxia Clin Nutr 17(6) 241–251Google Scholar
  36. 36.
    Wagner PD, Lundby C (2007) The lactate paradox: Does acclimatization to high altitude affect blood lactate during exercise? Med Sci Sports Exercise 39(5) 749–755Google Scholar
  37. 37.
    Bärtsch P, Saltin B (2008) General introduction to altitude adaptation and mountain sickness Scand J Med Sci Sports 18 Suppl 1 1–10Google Scholar
  38. 38.
    Braun B (2008) Effects of high altitude on substrate use and metabolic economy: cause and effect? Med Sci Sports Exercise 40(8) 1495–1500Google Scholar
  39. 39.
    Howald H, Hoppeler H (2003) Performing at extreme altitude: muscle cellular and sub cellular adapatations Eur J Appl Physiol 90(3–4) 360–364Google Scholar
  40. 40.
    Tschöp M, Morrison KM (2001) Weight loss at high altitude Adv Exp Med Biol 502 237–247Google Scholar
  41. 41.
    Mazzeo RS (2008) Physiological responses to exercise at altitude J Sports Med 1 1–8Google Scholar
  42. 42.
    Saey D, Michaud A, Couillard A, Cote CH, Mador MJ, LeBlanc P, Jobin J, Maltais F (2005) Contractile fatigue, muscle morphometry and blood lactate in chronic obstructive pulmonary disease Am J Resp Crit Care Med 171(10) 1109–1115Google Scholar
  43. 43.
    Green HJ, Burnett ME, D’Arsigny CL, O"Donell DE, Ouyang J, Webb KA (2008) Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease J Appl Physiol 105(3) 879–886Google Scholar
  44. 44.
    Saey D, Cote CH, Mador MJ, Laviolette L, LeBlanc P, Jobin J, Maltais F (2006) Assesment of muscle fatigue during exercise in chronic obstructive pulmonary disease Muscle Nerve 34(1) 62–71Google Scholar
  45. 45.
    Calvert LD, Singh SJ, Greenhaff PL, Morgan MD, Steiner MC (2008) The plasma ammonia response to cycle exercise in COPD Eur Resp J 31(4) 751–758Google Scholar
  46. 46.
    Cooper CB (2006) The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function Am J Med 119(10) Suppl 1 21–31Google Scholar
  47. 47.
    Lovejoy J, Newby FD, Gebhart SS, DiGirolamo M (1992) Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin Metabolism 42 22–27Google Scholar
  48. 48.
    Zawadzki JK, Wolfe RR, Mott DM, Lillioja S, Howard BV, Bogardus C (1988) Increased rate of Cori cycling in obese subjects with NIDDM and effect of weight reduction Diabetes 37 154–159Google Scholar
  49. 49.
    Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB et al (2002) Lactae induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling Am J Physiol Endocrinol Metab 283 233–240Google Scholar
  50. 50.
    Beckman KB, Ames BN (1998) The free radical theory of aging matures Physiol Rev 290 C844–C851Google Scholar
  51. 51.
    Harper ME, Bevilacqua K, Hagopian R, Weindrch R, Ramsey JJ (2004) Aging, oxidative stress and mitochondrial stress Acta Physiol Scand 182 321–331Google Scholar
  52. 52.
    Conley KE, Jubrias SA, Amara CE, Marcinek DJ (2007) Mitochondrial Dysfunction: Impact on exercise performance and cellular aging Exercise Sport Sci Rev 35(2) 43–49Google Scholar
  53. 53.
    Cha SH, Lane MD (2009) Central lactate metabolism suppresses food intake via the hypothalamic AMPkinase/malonyl-CoA signaling pathway Biochem Biophys Res Commun 386(1) 212–216Google Scholar
  54. 54.
    Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD (2009) Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock Critical Care Med 37(5) 1670–1677Google Scholar
  55. 55.
    Gasparovic H, Plestina S, Sutlic Z, Husedzinovic I, Coric V, Ivancan V, Jelic I (2007) Pulmonary lactate release following cardiopulmonary bypass Eur J Cardio-Thor Surg 32(6) 882–887Google Scholar
  56. 56.
    Marcello SM, Faria JE, de Aguilar-Nascimento OS, Pimenta LC, Alvareng DB, Nascimento D, Slhessarenko N (2009) Preoperative fasting of 2 hours minimizes insulin resistance and organic response to trauma after video-cholecystectomy: a randomized, controlled, clinical trial World J Surg 33 1158–1164Google Scholar
  57. 57.
    Schaafsma G (1997) Bioavailability of calcium and magnesium Eur J Clin Nutr 51 S13–S16Google Scholar
  58. 58.
    Brink EJ, van den Heuvel EGHM, Muijs T (2003) Comparison of six different calcium sources and meal type on true fractional calcium absorption in post meno pausal women Curr Topics Nutr Res 1 161–168Google Scholar
  59. 59.
    Lingström P, Liljeberg H, Björck I, Birkhed D (2000) The relationship between plaque pH and glycemic index of various breads Cariës Res 34 75–81Google Scholar
  60. 60.
    Östman E, Liljeberg H, Björck M (2002) Barley bread containing lactic acid improves glucose tolerance at a subsequent meal in healthy men and women Am Soc Nutr Sci 132 1173–1175Google Scholar
  61. 61.
    Maioli M, Mario G, Sanna M, Cherchi S, Dettori M, Manca E, Antonio G (2008) Sourdough-leavened bread improves postprandial glucose and insulin plasma levels in subjects with impaired glucose tolerance Acta Diabetol 45 91–96Google Scholar
  62. 62.
    Liljeberg HGM, Lönner CH, Björck IME (1995) Sourdough fermentation or addition of organic acids or corresponding salts to bread improves nutritional properties of starch in healthy humans J Nutr 125 1503–1511Google Scholar
  63. 63.
    Gustafsson K, Asp NG, Hagander B, Nyman M (1994) Dose response effects of boiled carrots and effects of carrots in lactic acid mixed meals on glycaemic responses and satiety Eur J Clin Nutr 48 386–396Google Scholar
  64. 64.
    Silberbauer C, Surnia Baumgartner D, Arnold M, Langhans W (2000) Prandial lactate infusion inhibits spontaneous feeding in rats Am J Physiol Regu Interg Comp Physiol 278 R646–R653Google Scholar
  65. 65.
    Astrup A (2008) The role of calcium in energy balance and obesity: the search for mechanisms Am J Clin Nutr 88 873–874Google Scholar
  66. 66.
    Schaafsma G (2009) Health benefits of milk beyond traditional nutrition Am J Dairy Technol 64 113–116Google Scholar
  67. 67.
    Christensen R, Lorenzen JK, Svith CR, Bartels EM, Melanson EL, Saris WH, Tremblay A, Astrup A, (2009) Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials Obes Rev 10(4) 475–486Google Scholar
  68. 68.
    Suminda K, Urdiales J, Donovan C (2006) Impact of flow rate on lactate uptake and gluconeogenesis in glucagon-stimulated perfused livers Am J Physiol Endocrinol Metab 209 E185–E191Google Scholar
  69. 69.
    Brouns F, Fogelholm M, van Hall G, Wagenmakers A, Saris WHM (1995) Chronic oral lactate supplementation does not affect lactate disappearance from blood after exercise Int J Sport Nutr 5 117–124Google Scholar
  70. 70.
    Azevedo Jr J, Tietz E, Two-Feathers T, Paul J, Chapman K (2007) Lactate, fructose and glucose oxidation profiles in sports drinks and the effect on exercise performance PloS ONE 2(9) e927–e936Google Scholar
  71. 71.
    Jeukendrup AE, Gleeson M (2004) Sport Nutrtion, an introduction to energy production and performance Human Kinetics, Leeds. UK ISBN 0736034048Google Scholar
  72. 72.
    Bujko J, Schreurs VV, Nolles JA, Verreijen AM et al (2007) Application of a [13CO2] breath test to study short-term amino acid catabolism during the postprandial phase of a meal Br J Nutr 97(5) 891–897Google Scholar

Copyright information

© Springer and CEC Editore 2010

Authors and Affiliations

  1. 1.Wageningen UniversityWageningen-HAN University of Applied SciencesNijmegenThe Netherlands
  2. 2.HAN University of Applied SciencesNijmegenThe Netherlands

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