Polycarprolactone ultrafine fiber membrane fabricated using a charge-reduced electrohydrodynamic process
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This paper introduces a modified electrospinning system for biomedical wound-healing applications. The conventional electrospinning process requires a grounded electrode on which highly charged electrospun ultrafine fibers are deposited. Biomedical wound-healing membranes, however, require a very low charge and a low level of remnant solvent on the electrospun membrane, which the conventional process cannot provide. An electrohydrodynamic process complemented with field-controllable electrodes (an auxiliary electrode and guiding electrodes) and an air blowing system was used to produce a membrane, with a considerably reduced charge and low remnant solvent concentration compared to one fabricated using the conventional method. The membrane had a small average pore size (102 nm) and high porosity (85.1%) for prevention of bacterial contamination.In vivo tests on rats showed that these directly electrospun fibrous membranes produced using the modified electrospinning process supported the good healing of skin burns.
Keywordsnanofibers electrospinning wound healing
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