Macromolecular Research

, Volume 15, Issue 6, pp 547–552 | Cite as

Poly(vinyl pyrrolidone) conjugated lipid system for the hydrophobic drug delivery

  • Hye Yun Lee
  • Seol A Yu
  • Kwan Ho Jeong
  • Young Jin Kim


Water soluble polymer, poly(vinyl pyrrolidone) was chosen to conjugate with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (N-succinyl DPPE) to make a new drug delivery system. PVP with an amine group (amino-PVP) was polymerized by free radical polymerization. The amine group of amino-PVP was conjugated with the carboxylic group ofN-succinyl DPPE. The resultant conjugate could form nanoparticles in the aqueous solution; these nanoparticles were termed a lipid-polymer system. The critical aggregation concentration was measured with pyrene to give a value of 1 × 10−3 g/L. The particle size of the lipid-polymer system, as measured by DLS, AFM and TEM, was about 70 nm. Lipophilic component in the inner part of the lipid-polymer system could derive the physical interaction with hydrophobic drugs. Griseofulvin was used as a model drug in this study. The loading efficiency and release profile of the drug were measured by HPLC. The loading efficiency was about 54%. The release behavior was sustained for a prolonged time of 12 days. The proposed lipid-polymer system with biodegradable and biocompatible properties has promising potential as a passive-targeting drug delivery carrier because of its small particle size.


PVP N-succinyl DPPE lipid nanoparticle drug delivery 


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Copyright information

© The Polymer Society of Korea and Springer 2007

Authors and Affiliations

  • Hye Yun Lee
    • 1
  • Seol A Yu
    • 1
  • Kwan Ho Jeong
    • 1
  • Young Jin Kim
    • 1
  1. 1.Department of Applied Chemistry and Biological EngineeringChungnam National UniversityDaejeonKorea

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