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Poly(vinyl pyrrolidone) conjugated lipid system for the hydrophobic drug delivery

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Abstract

Water soluble polymer, poly(vinyl pyrrolidone) was chosen to conjugate with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (N-succinyl DPPE) to make a new drug delivery system. PVP with an amine group (amino-PVP) was polymerized by free radical polymerization. The amine group of amino-PVP was conjugated with the carboxylic group ofN-succinyl DPPE. The resultant conjugate could form nanoparticles in the aqueous solution; these nanoparticles were termed a lipid-polymer system. The critical aggregation concentration was measured with pyrene to give a value of 1 × 10−3 g/L. The particle size of the lipid-polymer system, as measured by DLS, AFM and TEM, was about 70 nm. Lipophilic component in the inner part of the lipid-polymer system could derive the physical interaction with hydrophobic drugs. Griseofulvin was used as a model drug in this study. The loading efficiency and release profile of the drug were measured by HPLC. The loading efficiency was about 54%. The release behavior was sustained for a prolonged time of 12 days. The proposed lipid-polymer system with biodegradable and biocompatible properties has promising potential as a passive-targeting drug delivery carrier because of its small particle size.

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Authors and Affiliations

  1. Department of Applied Chemistry and Biological Engineering, Chungnam National University, 305-764, Daejeon, Korea

    Hye Yun Lee, Seol A Yu, Kwan Ho Jeong & Young Jin Kim

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  1. Hye Yun Lee
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  2. Seol A Yu
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  3. Kwan Ho Jeong
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  4. Young Jin Kim
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Correspondence to Young Jin Kim.

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Lee, H.Y., Yu, S.A., Jeong, K.H. et al. Poly(vinyl pyrrolidone) conjugated lipid system for the hydrophobic drug delivery. Macromol. Res. 15, 547–552 (2007). https://doi.org/10.1007/BF03218829

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  • DOI: https://doi.org/10.1007/BF03218829

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