Macromolecular Research

, Volume 15, Issue 5, pp 469–472 | Cite as

RGD Island Spacing Controls Phenotype of Primary Human Fibroblasts Adhered to Ligand-Organized Hydrogels

  • Min-Su Bae
  • Kuen Yong Lee
  • Yoon Jeong Park
  • David J. Mooney


We demonstrated that the nanoscale organization of RGD peptides in alginate gels, designed as a synthetic ECM, regulated the adhesion and proliferation of primary human fibroblasts. Cell spreading and growth were strongly correlated with the distance between islands of the peptides, irrespective of the same bulk RGD density in the gels. The approach of controlling the distribution and spacing of adhesion ligands at the nanometer level may be critical in the design and function of synthetic ECMs for tissue engineering applications.


Alginate Primary Fibroblast Nanometer Level Primary Human Fibroblast Adhesion Ligand 
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Copyright information

© The Polymer Society of Korea and Springer 2007

Authors and Affiliations

  • Min-Su Bae
    • 1
  • Kuen Yong Lee
    • 1
  • Yoon Jeong Park
    • 2
  • David J. Mooney
    • 3
  1. 1.Department of BioengineeringHanyang UniversitySeoulKorea
  2. 2.Craniomaxillofacial Reconstructive Science MajorSchool of Dentistry, Seoul National UniversitySeoulKorea
  3. 3.Division of Engineering and Applied SciencesHarvard UniversityCambridgeUSA

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