RGD Island Spacing Controls Phenotype of Primary Human Fibroblasts Adhered to Ligand-Organized Hydrogels
We demonstrated that the nanoscale organization of RGD peptides in alginate gels, designed as a synthetic ECM, regulated the adhesion and proliferation of primary human fibroblasts. Cell spreading and growth were strongly correlated with the distance between islands of the peptides, irrespective of the same bulk RGD density in the gels. The approach of controlling the distribution and spacing of adhesion ligands at the nanometer level may be critical in the design and function of synthetic ECMs for tissue engineering applications.
KeywordsAlginate Primary Fibroblast Nanometer Level Primary Human Fibroblast Adhesion Ligand
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