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Macromolecular Research

, Volume 17, Issue 12, pp 1025–1031 | Cite as

Synthesis and characterization of biodegradable thermo- and pH-sensitive hydrogels based on pluronic F127/poly(ε-caprolactone) macromer and acrylic acid

  • Sanping Zhao
  • Mengjie Cao
  • Jun Wu
  • Weilin Xu
Article

Abstract

Several kinds of biodegradable hydrogels were prepared viain situ photopolymerization of Pluronic F127/poly(ε-caprolactone) macromer and acrylic acid (AA) comonomer in aqueous medium. The swelling kinetics measurements showed that the resultant hydrogels exhibited both thermo- and pH-sensitive behaviors, and that this stimuli-responsiveness underwent a fast reversible process. With increasing pH of the local buffer solutions, the pH sensitivity of the hydrogels was increased, while the temperature sensitivity was decreased.In vitro hydrolytic degradation in the buffer solution (pH 7.4, 37 °C), the degradation rate of the hydrogels was greatly improved due to the introduction of the AA comonomer. Thein vitro release profiles of bovine serum albumin (BSA)in-situ embedded into the hydrogels were also investigated: the release mechanism of BSA based on the Peppas equation was followed Case II diffusion. Such biodegradable dual-sensitive hydrogel materials may have more advantages as a potentially interesting platform for smart drug delivery carriers and tissue engineering scaffolds.

Keywords

photopolymerization temperature sensitivity pH sensitivity hydrolytic degradation drug delivery 

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Copyright information

© The Polymer Society of Korea and Springer 2009

Authors and Affiliations

  1. 1.Key Laboratory of Green Processing and Functional Textiles of New Textile Materials of Ministry of EducationWuhan University of Science and EngineeringWuhanP.R. China

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