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Temperature-induced release of all-trans-retinoic acid loaded in solid lipid nanoparticles for topical delivery

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Abstract

The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at 4 °C and at 37 °C were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical Sciences, Chonbuk National University Medical School, 561-712, Jeonju, Jellabuk-Do, Korea

    Chang-Moon Lee & Hwan-Jeong Jeong

  2. Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University, 500-757, Gwangju, Korea

    Ji-Won Park

  3. Department of Advanced Chemicals, Chonnam National University, 500-757, Gwangju, uKorea

    Jin Kim

  4. Faculty of Chemical Engineering, Chonnam National University, 500-757, Gwangju, Korea

    Ki-Young Lee

Authors
  1. Chang-Moon Lee
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  2. Hwan-Jeong Jeong
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  3. Ji-Won Park
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  4. Jin Kim
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  5. Ki-Young Lee
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Correspondence to Ki-Young Lee.

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These authors contributed equally to this work.

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Lee, CM., Jeong, HJ., Park, JW. et al. Temperature-induced release of all-trans-retinoic acid loaded in solid lipid nanoparticles for topical delivery. Macromol. Res. 16, 682–685 (2008). https://doi.org/10.1007/BF03218581

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  • DOI: https://doi.org/10.1007/BF03218581

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