Macromolecular Research

, Volume 16, Issue 8, pp 682–685 | Cite as

Temperature-induced release of all-trans-retinoic acid loaded in solid lipid nanoparticles for topical delivery

  • Chang-Moon Lee
  • Hwan-Jeong Jeong
  • Ji-Won Park
  • Jin Kim
  • Ki-Young Lee


The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension instability of ATRA in aqueous solution. The photodegradation of ATRA by light was reduced by incorporation in SLN. The loading efficiency of ATRA in SLN was higher than 95% (w/w). The amounts of ATRA released from SLN at 4 °C and at 37 °C were less than 15% and more than 60% (w/w) for 96 h, respectively. The ATRA-loaded SLN can be used as a potential carrier for topical delivery.


all-trans-retinoic acid coconut oil curdlan solid lipid nanoparticle topical delivery 


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Copyright information

© The Polymer Society of Korea and Springer 2008

Authors and Affiliations

  • Chang-Moon Lee
    • 1
  • Hwan-Jeong Jeong
    • 1
  • Ji-Won Park
    • 2
  • Jin Kim
    • 3
  • Ki-Young Lee
    • 4
  1. 1.Department of Nuclear Medicine, Research Institute of Clinical Medicine, Institute for Medical SciencesChonbuk National University Medical SchoolJeonju, Jellabuk-DoKorea
  2. 2.Interdisciplinary Program of Perfume and CosmeticsChonnam National UniversityGwangjuKorea
  3. 3.Department of Advanced ChemicalsChonnam National UniversityGwangjuuKorea
  4. 4.Faculty of Chemical EngineeringChonnam National UniversityGwangjuKorea

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