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Macromolecular Research

, Volume 11, Issue 1, pp 42–46 | Cite as

In vitro biodegradability and surface properties of block copoly(ester-ether)s consisting of poly(L-lactide)and polyether

  • Chan Woo Lee
  • Yoshiharu Kimura
Article

Abstract

Cell attachment and proliferation on the polymer films of triblock copolymer(ester-ether)s comprising poly(L-lactide)(PLLA) and poly(oxyethylene-co-oxypropylene)(PN) were investigated using 3T3 fibroblasts. It was found that on the tissue culture polystyrene(TCPS) and the PLLA control film the cells could spread well while on the copolymer films the cells showed a rounded morphology without spreading and proliferated weakly. Especially, little cells proliferated on the films of copolymer having a LN composition of 20 wt%. While the water absorption of the copolymer films increased with increasing PN content, the contact angle against water of copolymer films immersed in aqueous medium was almost identical, being slightly lower than that of the PLLA film. These properties were compatible with the results of cell attachment. Thein vitro hydrolysis of the films of triblock and multiblock type copolymers was faster with increasing PN content. The increased hydrolyzability, the flexibility and the decreased cell attachment suggested that these copolymers may have high potential as biodegradable materials for medical use.

Keywords

cell attachment proliferation fibroblast flexibility biodegradable material 

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Copyright information

© The Polymer Society of Korea and Springer 2003

Authors and Affiliations

  • Chan Woo Lee
    • 1
  • Yoshiharu Kimura
    • 2
  1. 1.Department of Innovative Industrial TechnologyHoseo UniversityAsan-CityKorea
  2. 2.Department of Polymer Science and EngineeringKyoto Institute of TechnologyKyotoJapan

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