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Archives of Pharmacal Research

, Volume 21, Issue 1, pp 70–72 | Cite as

Total synthesis of fentanyl

  • Young-Ger Suh
  • Kyung-Ho Cho
  • Dong-Yoon Shin
Notes

Abstract

Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenyle-thylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

Key words

Fentanyl Anagesics Piperidine Aminomethano desilyltion-cyclization 

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References Cited

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Young-Ger Suh
    • 1
  • Kyung-Ho Cho
    • 1
  • Dong-Yoon Shin
    • 1
  1. 1.College of PharmacySeoul National UniversitySeoulKorea

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