Total synthesis of fentanyl
Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenyle-thylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.
Key wordsFentanyl Anagesics Piperidine Aminomethano desilyltion-cyclization
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