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Archives of Pharmacal Research

, Volume 21, Issue 1, pp 12–16 | Cite as

Inhibitory effect of lignans from the rhizomes ofCoptis japonica var.dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells

  • Jae Youl Cho
  • Jisoo Park
  • Eun Sook Yoo
  • Kazuko Yoshikawa
  • Kyong Up Baik
  • Jongsoo Lee
  • Myung Hwan Park
Research Articles

Abstract

The inhibitory effect of 10 lignan constituents isolated from the rhizomes ofCoptis japonica var.dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, vvoorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 µg/ml. The results are first report that the lignans isolated fromCoptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect ofCoptis japonica through the inhibition of TNF-α production.

Key words

TNF-α RAW264.7 LPS Coptis japonica Lignan Pinoresinol Woorenoside Lariciresinol glycoside ELISA 

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Jae Youl Cho
    • 1
  • Jisoo Park
    • 1
  • Eun Sook Yoo
    • 1
  • Kazuko Yoshikawa
    • 2
  • Kyong Up Baik
    • 1
  • Jongsoo Lee
    • 1
  • Myung Hwan Park
    • 1
  1. 1.R & D CenterDaewoong Pharm. Co. Ltd.Sungnam, Kyunggi-DoKorea
  2. 2.Faculty of Pharmaceutical SciencesTokushima Bunri UniversityYamashiro-cho, TokushimaJapan

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