European Journal of Clinical Pharmacology

, Volume 40, Supplement 1, pp S65–S67 | Cite as

Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole

  • Y. A. Kesäniemi
  • T. A. Miettinen


Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14α-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.


Neomycin benzodiazepine ketoconazole cholesterol malabsorption cholesterol synthesis serum cholesterol lowering 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Y. A. Kesäniemi
    • 1
  • T. A. Miettinen
    • 2
  1. 1.Department of Internal MedicineUniversity of OuluFinland
  2. 2.Second Department of MedicineUniversity of HelsinkiHelsinkiFinland

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