Mitochondria and aging: innocent bystanders or guilty parties?
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There are many theories of aging and a number ofthem encompass the role of mitochondria in this process. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. However, there is little evidence that these mutations could affect the functioning of aging tissues.
Keywordsmitochondria mitochondrial DNA reactive oxygen species skin aging
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- Chinnery PF, Taylor GA, Howell N, Brown DT, Parsons TJ, Turnbull DM, 2001. Point mutations of the mtDNA control region in normal and neurodegenerative human brains. 68: 529–532.Google Scholar
- Seibel P, Di Nunno C, Kukat C, Schäfer I, Del Bo R, Bordoni A, et al. 2008. Cosegregation of novel mitochondrial 16S rRNA gene mutations with the age-associated T414G variant in human cybrids. Nucleic Acids Res. Sep 16. [Epub ahead of print] PMID: 18796524 doi:10.1993/nar/gkn592Google Scholar
- Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC, 1989. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci USA 86: 7952–7956.CrossRefPubMedGoogle Scholar
- Zegarska B, Woźniak M, 2006. Reasons of endogenous aging of the skin. Geront Pol 14: 153–159.Google Scholar