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Journal of Applied Genetics

, Volume 48, Issue 3, pp 273–275 | Cite as

Lack of association of HLA—C alleles with late-onset psoriasis in the northern Polish population

  • Aneta Szczerkowska-Dobosz
  • Katarzyna Niespodziana
  • Krzysztof Rębała
  • Joanna Garstecka
  • Magdalena Lange
  • Wioletta Barańska-Rybak
Short Communication

Abstract

The HLA (human leukocyte antigen) Cw*06 allele demonstrates the strongest association with susceptibility to early-onset psoriasis in most populations. Recent data have indicated that late-onset psoriasis (LOP) demonstrates only a weak association with Cw*0602, and suggest that this type of psoriasis may represent a distinct subtype of the disease. The aim of this study was to compare the frequency of human leukocyte antigen C (HLA—C) alleles in patients with LOP and in healthy subjects within the same ethnic group in northern Poland. HLA—C alleles of 89 patients with psoriasis with onset at the age of 40 y or later and 80 control subjects were determined by a polymerase chain reaction (PCR), low-resolution method. The results showed that the Cw*05 allele was detected less frequently in patients with LOP than in control subjects, but this failed to retain significance after correction for multiple comparisons. There were no differences in the frequency of other HLA—C alleles between the patients and the control group. Our results confirm no association between HLA—C alleles and LOP in the northern Polish population. The lack of this association supports the hypothesis about different genetic back-grounds of early- and late-onset psoriasis.

Keywords

HLA-Cw*06 late-onset psoriasis PSORS1 

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References

  1. Allen MH, Veal C, Faassen A, Powis SH, Vaughan RW, Trembath RC, Barker JN, 1999. A non-HLA gene within the MHC inpsoriasis. Lancet 353: 1589–1590.CrossRefPubMedGoogle Scholar
  2. Allen MH, Ameen H, Veal C, Evans J, Ramrakha-Jones V, Marsland AM, et al. 2004. The major psoriasis susceptibility locus PSORS1 is not a risk factor for late onset psoriasis. J Invest Dermatol 124: 103–106.CrossRefGoogle Scholar
  3. Asumalahti K, Ameen M, Suomela S, Hagforsens E, Michaelssons G, Munro M, et al. 2003. Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis. J Invest Dermatol 120: 627–632.CrossRefPubMedGoogle Scholar
  4. Asumalahti K,LaitinenT, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, et al. 2000. Acandidategene for psoriasisnear HLA-C, HCR (Pg8) ishighly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet 9: 1533–1542.CrossRefPubMedGoogle Scholar
  5. Gudjonsson J, Karason A, Runarsdottir H, 2006. Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients - an analysis of 1019 HLA-C- and HLA-B-typed patients. J Invest Dermatol 126: 740–745.CrossRefPubMedGoogle Scholar
  6. Henseler T, Christophers E, 1985. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13: 450–456.CrossRefPubMedGoogle Scholar
  7. Johnston A, Gudjonsson J, Sigmundsdottir H, Lowe T, Valdimarsson H, 2004. Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin homing CD8(+) T cells. Clin Exp Immunol 138: 83–89.CrossRefPubMedGoogle Scholar
  8. Łuszczek W, Kubicka W, Cisło M, Nockowski P, Woszczek G, Baran E, Kuśmierczyk P, 2003. Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients. Immunol Lett 85: 59–64.CrossRefPubMedGoogle Scholar
  9. Szczerkowska-Dobosz A, Placek W, Szczerkowska Z, Roszkiewicz J, 1996. Psoriasis vulgaris with the early and late onset-HLA-phenotype correlations. Arch Immun Ther Exp 44: 265–269.Google Scholar
  10. Trembath RC, Clough RL, Rosbotham JL, Jones AB, Camp RD, Frodsham A, et al. 1997. Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum Mol Genet 6: 813–820.CrossRefPubMedGoogle Scholar

Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2007

Authors and Affiliations

  • Aneta Szczerkowska-Dobosz
    • 1
  • Katarzyna Niespodziana
    • 2
  • Krzysztof Rębała
    • 2
  • Joanna Garstecka
    • 3
  • Magdalena Lange
    • 1
  • Wioletta Barańska-Rybak
    • 1
  1. 1.Department of DermatologyMedical University of GdańskGdańskPoland
  2. 2.Department of Forensic MedicineMedical UniversityGdańskPoland
  3. 3.Department of DermatologyNicolaus Copernicus HospitalGdańskPoland

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