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A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese

  • Zhong Shi-Long
  • Shufeng Zhou
  • Min Huang
Article

Summary

Objective

This study was to compare the frequencies of genetic polymorphisms ofGSTM1, GSTT1, andGSTP1 in Uygur Chinese with those in Han Chinese.

Methods

GSTM1 andGSTT1 polymorphisms were analyzed by a PCR-Multiplex procedure, whereasGSTP1 polymorphism was analyzed by PCR-RFLP.

Results

The frequency ofGSTM1 null genotype in Han Chinese (56.1%) was similar to that in Uygur Chinese (53.2%) (P=0.592), whilst the frequency ofGSTT1 null genotype in Han Chinese (50.0%) was significantly (P< 0.05) higher than that of Uygur Chinese (26.6%).GSTP1 had a genotype distribution of 60.7% I/I, 35.2% I/V and 4.1% V/V in Han Chinese, and 51.3% I/I, 40.2% I/V and 8.4% V/V in Uygur Chinese.

Conclusion

There is marked ethnic difference in the mutant frequencies ofGSTT1 andGSTP1, but notGSTM1, between Uygur and Han Chinese.

Keywords

Glutathione S-transferase Genotype Uygur Chinese Han Chinese 

Abbreviation

RFLP

restriction fragment length polymorphism

GST

glutathione S-transferase

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Zhong Shi-Long
    • 1
  • Shufeng Zhou
    • 2
  • Min Huang
    • 1
  1. 1.Institute of Clinical Pharmacology, School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouP.R. China
  2. 2.Department of Pharmacy, Faculty of ScienceNational University of SingaporeSingapore

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