A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese

  • Zhong Shi-Long
  • Shufeng Zhou
  • Min Huang



This study was to compare the frequencies of genetic polymorphisms ofGSTM1, GSTT1, andGSTP1 in Uygur Chinese with those in Han Chinese.


GSTM1 andGSTT1 polymorphisms were analyzed by a PCR-Multiplex procedure, whereasGSTP1 polymorphism was analyzed by PCR-RFLP.


The frequency ofGSTM1 null genotype in Han Chinese (56.1%) was similar to that in Uygur Chinese (53.2%) (P=0.592), whilst the frequency ofGSTT1 null genotype in Han Chinese (50.0%) was significantly (P< 0.05) higher than that of Uygur Chinese (26.6%).GSTP1 had a genotype distribution of 60.7% I/I, 35.2% I/V and 4.1% V/V in Han Chinese, and 51.3% I/I, 40.2% I/V and 8.4% V/V in Uygur Chinese.


There is marked ethnic difference in the mutant frequencies ofGSTT1 andGSTP1, but notGSTM1, between Uygur and Han Chinese.


Glutathione S-transferase Genotype Uygur Chinese Han Chinese 



restriction fragment length polymorphism


glutathione S-transferase


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Zhong Shi-Long
    • 1
  • Shufeng Zhou
    • 2
  • Min Huang
    • 1
  1. 1.Institute of Clinical Pharmacology, School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouP.R. China
  2. 2.Department of Pharmacy, Faculty of ScienceNational University of SingaporeSingapore

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