Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets

  • Wang F. M. 
  • Yao T. W. 
  • Zeng S. 


Ten adult volunteers with an average age 28 years were given a single oral dose of six tablets of Ginkgo biloba extract. Quercetin and kaempferol in different period of human urine were determined by using RP-HPLC.

The results showed the elimination rate constantk and the absorption rate constantk a of quercetin were slightly more than that of kaempferol; and the absorption half-life (t1/2a), the elimination half-life (t1/2) and tmax of qurcetin were less than that of kaempferol, the differences were, however, not statistically significant.

The mean values ofk a were 0.61 h−1 and 0.55 h−1, t1/2a 1.51h and 1.56h,k 0.37 h−1 and 0.30 h−1, t1/2 2.17h and 2.76h, Tmax 2.30h and 2.68h for quercetin and kaempferol, respectively, which mean absorption and elimination of quercetin and kaemperferol are 0.17% and 0.22%, respectively.

Quercetin and kaemferol are excreted in the human urine mainly as glucuronides.


Ginkgo biloba extract kaempferul quercetin Disposition Glucuronide Excretion 


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  1. 1.
    Hollman, PC; de-Vries, JH; van-Leeuwen, SD; Mengelers, MJ; Katan, MB. (1995) Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am. J. Clin. Nutr. 62(6): 1276–82PubMedGoogle Scholar
  2. 2.
    Hollman, PC. Ph. D. Thesis, (1997) State Institute for Quality Control of Agricultural Products (RIKILT-DLO). Wageningen. Netherlands.Google Scholar
  3. 3.
    Nielsen, SE; Kall, M; Justesen, U; Schou, A; Dragsted, LO. (1997) Human absorption and excretion of flavonoids after broccoli consumption. Cancer-Lett. 114(1–2): 173–4.CrossRefPubMedGoogle Scholar
  4. 4.
    Wojcicki J, Gawronska-Szklarz B, Bieganowski W, Patalan M, Smulski HK, Samochowiec L, Zakrzewski J. Comparative pharmacokinetics and bioavailability of flavonoid glycosides of Ginkgo biloba after a single oral administration of three formulations to healthy volunteers. Mater Med Pol, 1995;27(4):141–6PubMedGoogle Scholar
  5. 5.
    Hollman, -P-C; van-Trijp, -J-M; Buysman, -M-N; van-der-Gaag, -M-S; Mengelers, -M.-J; de-Vries, -J-H; Katan, -M-B. (1997) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS-Lett. 418(1–2): 152–6.CrossRefPubMedGoogle Scholar

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© Springer-Verlag 2003

Authors and Affiliations

  • Wang F. M. 
    • 1
    • 2
  • Yao T. W. 
    • 1
  • Zeng S. 
    • 1
  1. 1.Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical SciencesZhejiang UniversityHangzhou, ZhejiangPeople’s Republic of China
  2. 2.Women’s Hospital School of Medicine Zhejiang UniversityHangzhou, ZhejiangPeople’s Republic of China

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