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Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets

  • Wang F. M. 
  • Yao T. W. 
  • Zeng S. 
Article

Summary

Ten adult volunteers with an average age 28 years were given a single oral dose of six tablets of Ginkgo biloba extract. Quercetin and kaempferol in different period of human urine were determined by using RP-HPLC.

The results showed the elimination rate constantk and the absorption rate constantk a of quercetin were slightly more than that of kaempferol; and the absorption half-life (t1/2a), the elimination half-life (t1/2) and tmax of qurcetin were less than that of kaempferol, the differences were, however, not statistically significant.

The mean values ofk a were 0.61 h−1 and 0.55 h−1, t1/2a 1.51h and 1.56h,k 0.37 h−1 and 0.30 h−1, t1/2 2.17h and 2.76h, Tmax 2.30h and 2.68h for quercetin and kaempferol, respectively, which mean absorption and elimination of quercetin and kaemperferol are 0.17% and 0.22%, respectively.

Quercetin and kaemferol are excreted in the human urine mainly as glucuronides.

Keywords

Ginkgo biloba extract kaempferul quercetin Disposition Glucuronide Excretion 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Wang F. M. 
    • 1
    • 2
  • Yao T. W. 
    • 1
  • Zeng S. 
    • 1
  1. 1.Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical SciencesZhejiang UniversityHangzhou, ZhejiangPeople’s Republic of China
  2. 2.Women’s Hospital School of Medicine Zhejiang UniversityHangzhou, ZhejiangPeople’s Republic of China

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