Summary
Metabolism of tramadol, 1-(m-methyoxyphenyl)-2-(dimethyllamminomethyl)-cyclohexan-1-ol, in man was investigated using urine of healthy male volunteers. The drug was administered orally and the urine was extracted and analysed by gas chromatography. Tramadol and two of its metabolites were detected in urine. The major metabolic pathways were O- and N-demethylation and a combination of these metabolic steps. Tramadol was excreted mainly unchanged, about 96%. Thus, biotransformation was not significant in the elimination of the drug from the body.
Similar content being viewed by others
References
Friderichs E., Felgenhauer E., Jonschaap F., Osterloh G. (1978): Arznneim-Forsch 28, 122–134.
Osterloh G., Friderichs E., Fegenhauer E., Gumzier W.A., Henmii Z., Kitano T., Nakamura H., Ishii T. (1978): General Pharmacological studies on tramadol, a powerful analgesic agent, Arzneim.-Forsch, 28, 135–151.
Lagler F., Helm F., Etzel V., Kiel H. (1978): Toxicological investigation with tramadol, a new analgesic. Arzneim.-Forsch 28. 164–172.
Erlacin S., Frankus E., Lintz W. (1980): Metabolism of tramadol in man and animals, Naunyn-Schmiedeberg’s Arch. Pharmacol. 313 Suuppl. R 202.
Paxton J.W. (1981): Elementary pharmacokinetics in clinical practice 4. Genetic environmental and age influences on pharmacokinetics. The new Zealand Med. J., 697, 423–425.
Flick K., Frankus E., Friderichs E. (1978): Investigation of the chemical structure and analgesic property of phenylsubstituted aminomethylcyclohexanol. Arzneim.-Forsch, 28, 107–113.
Ogunleye D.S., Mustapha A. (1988): Gas liquid chromatographic determination of tramadol, a centrally acting analgesic agent. Nigerian J. of Pharm. Sci. 4, 65–66.
Testa B., Jenner P. (1976): Drug metabolism: Chemical and biochemical aspects. In Drugs and Pharmaceutical Sciences, Dekker Inc., New York, 4, 4–9, 82
Ofoegbu R.O., Mbonu O.O. (1985): Current Ther. Res. 305–307.
Conney A.H. (1967): Pharmacological implications of microsomal enzyme induction. Pharmacol Rev., 19, 317–366.
Evans D.A.P., White T.A. (1964): Human acetylation polymorphism, J. Lab. Clin. Med., 63, 394–403.
Lintz W. (1980): Pharmacokinetics of tramadol in man and animals. Naunyn-Schmiedeberg’s Arch. Pharmacol., 313, Suppl. R53.
Skeith MD et. al. (1968): The renal excretion of indomethacin and its inhibition by probenecid. Clin. Pharmacol. Ther. 9, 89.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ogunleye, D.S. Investigation of racial variations in the metabolism of tramadol. Eur. J. Drug Metab. Pharmacokinet. 26, 95–98 (2001). https://doi.org/10.1007/BF03190382
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03190382