Advertisement

Trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals

  • X. D. Liu
  • J. Chen
Article
  • 14 Downloads

Summary

A trapezoidal area method for simulating physiological pharmacokinetics of drugs in animals is proposed. Concentrations of ethoxybenzamide in rat tissues and diazepam in human plasma were simulated. The results showed that profiles of concentrations vs time in the body with this method were in a good agreement with those obtained with the Rang-Katta method. As compared with the Rang-Katta method, the present method has two special advantages: the time course of drug concentration in tissue can be estimated using simple equations and the speed for simulation is faster.

Keywords

Trapezoidal area method physiological pharmacokinetics 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Benowitz N., Forsyth R.P., Melmon K.L., Rowland M. (1974): Lidocaine disposition kinetics in monkey and man I. Prediction by a perfusion model. Clin. Pharmacol. Ther., 16, 87–98.PubMedGoogle Scholar
  2. 2.
    Gabrielsson J.L., Paalzow L.K., Nordstrom L. (1984): A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat. J. Pharmacokinet Biopharm., 12, 149–165,CrossRefPubMedGoogle Scholar
  3. 3.
    Galbraith R.W.M., Dedrick R.L., Shrager R., Mellett L.B. (1977): A model for the kinetics of distribution of actinomycin-D in the beagle dog. J. Pharmacol. Exp. Ther., 200, 469–478.PubMedGoogle Scholar
  4. 4.
    Liu X.D., Huang S.K. (1988): Linear system analysis and physiological model in estimating disposition kinetics of sophocarpine in rat Acta Pharmacol. Sin., 23, 481–489.Google Scholar
  5. 5.
    Igari Y., Sugiyama Y., Awazu S., Hanano M. (1982): Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat J. Pharmacokinet Biopharm., 10, 53–75.CrossRefPubMedGoogle Scholar
  6. 6.
    Lin J.H., Sugiyama Y., Awazu S., Hanano M. (1982): Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data. J. Pharmacokinet Biopharm., 10, 649–661.CrossRefPubMedGoogle Scholar
  7. 7.
    Igari Y., et al. (1983): Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model. J. Pharmacokinet. Biopharm., 11, 577–592.CrossRefPubMedGoogle Scholar
  8. 8.
    Klotz U., Antonin K.H., Bieck P.R. (1976): Pharmacokinetics and plasma binding of diazepam in man, dog, guinea pig and rat J. Pharmacol. Exp. Ther., 199, 67–73.PubMedGoogle Scholar
  9. 9.
    Klotz A., et al. (1975): The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J. Clin. Invest, 55, 347–359.CrossRefPubMedGoogle Scholar
  10. 10.
    Li B.X., Fei Z.M., Huang S.K., Liu X.D. (1987): Physiological model and numerical integrating algorithm. J. China Pharmaceutical University, 18, 273–276.Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • X. D. Liu
    • 1
  • J. Chen
    • 1
  1. 1.Department of PharmacologyChina Pharmaceutical UniversityNanfing, Jiangsu ProvincePeople’s Republic of China

Personalised recommendations