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Inducibility of rat brain drug-metabolizing enzymes

  • J. F. Ghersi-Egea
  • B. Walther
  • R. Perrin
  • A. Minn
  • A. Minn
  • G. Siest
Article

Summary

Cytochrome P450 from rat brain mitochondrial and microsomal fractions was found to be inducible by 3-methylcholanthrene, both in quantity of enzyme and in activity towards 7-ethoxyresorufin, which is a model substrate for the cytochrome P450 isoform specifically induced by 3-methylcholanthrene. Conversely, a phénobarbital treatment resulted in an induction of the microsomal cytochrome P450 only. On the other hand, the microsomal 1-naphthol-UDP-glucuronosyl transferase and epoxide hydrolase seemed to be non-inducible by 3-methylcholanthrene or by phénobarbital. The toxicological implications of these data are discussed.

Key words

Drug metabolism brain induction cytochrome P450 UDP-glucuronosyl transferase 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. F. Ghersi-Egea
    • 1
  • B. Walther
    • 1
  • R. Perrin
    • 1
  • A. Minn
    • 1
  • A. Minn
    • 1
  • G. Siest
    • 1
  1. 1.Centre du MédicamentUniversité de NancyNancyFrance

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