Summary
The biliary excretion of Olsalazine sodium (ADS) was studied by three different methods in healthy volunteers and in patients. 1 g ADS in a 2% solution was infused during 1 h into jejunum in six healthy volunteers via a three lumen sond. The bile was collected, during 2.5–6 h, proximal of an occlusive balloon on the three lumen sond. 10 mg ADS was given i.v. to five healthy volunteers and the bile was collected during 3–4.5 h with the same type of three lumen sond as used in the first experiment. 1 g ADS was given orally to three patients, with a T-tube inserted into coleducus at surgery. The bile was collected via the T-tube for 24 h.
The mean biliary excretion of the jejunal dose was 0.41% (0.22% if one subject, who probably had a beckflow of the instillation fluid, is omitted). In patients, the mean excretion with bile of ADS was 0.35% and of ac-5-ASA 0.17%. Due to the short collection time after jejunal infusion and the probably incomplete collection of bile in both enteral studies the biliary excretion was estimated to be less than 2% as ADS and less than 1% as ac-5-ASA.
The biliary excretion of an i.v. dose showed large individual variations (0.16–12.2%) which were not correlated to the length of the collection time. The total excretion was estimated to be less than 20% as ADS. No metabolites were detected after the i.v. dose.
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References
Azad Khan A.K., (1977): Lancet. An experiment to determine the active therapeutic moiety of sulphasalazine, ii, 892–895.
van Hees P.A.M., Bakker J.H., van Tongeren J.H.M., (1980): Gut. Effect of sulphapyridine, 5-aminosalicylic acid and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine,21, 632–635.
Campieri M., Lanfranchi G.A., Bazzocchi G., Brignola C, Sarti F., Franzin G., Battocchia A., Labo G., Dal Monte P.R., (1981): Lancet. Treatment of ulcerative colitis with high dose 5-aminosalicylic acid enemas,2, 270–271.
Klotz U., Maier K., Fischer C, Heinkel K., (1980): N. Eng. J. Med. Therapeutic efficacy of sulphasalazine and its metabolites in patients with ulcerative colitis and Crohn’s disease,303, 1499–1502.
Selby W.S., Barr G.D., Ireland A., Mason CH., Jewell D.P., (1985): Br. Medical J. Olsalazine in active ulcerative colitis,291, 1373–1375.
Hetzel D.J., Shearman D.J.C, Bochner F., Imhoff D.M., Gibson G.E., Fitch R.J., Hecker R., LaBrooy J., Rowland R., Manuscript. Azodisalicylate (ADS) in the treatment of active ulcerative colitis. A placebo controlled clinical trial and assessment of drug disposition.
Sandberg-Gertzén H., Järnerot G., Kraaz W., (1986): Azodisal sodium in the treatment of ulcerative colitis. A study of tolerance and relapse prevention properties Gastroenterology90, 1024–1030.
Bodin N-O. (Personnal communication).
Rollins D.E., Klaassen CD., (1979): Clinical Pharmacokinetics. Biliary Excretion of Drugs in Man,4, 368–379.
Brogard J.M., Arnaud J.P., Blicklé J.F., Lavillaureix J., (1984): Antimicrob. Agents Chemother. Biliary Elimination of Apalcillin in humans,26, 428–430.
Davenport H.W., (1971): Year Book Medical Publ. Incorp. Secretion of the Bile. Third edition, 129–138.
Davidson J.S., (1984): Physiology of Extrahepatic Bile Transport in Textbook of Gastroenterology. Ed:s Bouchier I.A.D., Allan R.N., Hodgson H.J.F., Keighley M.R.B., Balliere Tindall, 1376–1380.
Peeters T.L., Vantrappen G., Janssens, (1980): Gastroenterology. Bile Acid Output and the Interdigestive Migration Motor Complex in Normals and in Cholesystectomy Patients,79, 678–681.
Svenberg T., Christofides N.D., Fitzpatrick M.L., Areola-Ortiz F., Bloom S.R., Welbourn R.B., (1982): Gut. Interdigestive Biliary Output in Man: Relationship to fluctuations in plasma motilin and effect of atropine,23, 1024–1028.
van Hogezand R.A., van Hees P.A.M., Zwaneburg B., van Rossum J.M., van Tongeren J.H.M., (1985): Gastroenterology. Disposition of Disodium Azodisalicylate in Healthy Subjects. A possible New Drug for Inflammatory Bowel Disease,88, 717–722.
Ryde M. Manuscript. The pharmacokinetics of Olsalazine sodium in healthy volunteers after single i.v. dose, oral dose with and without food and increasing oral doses within a possible therapeutic range.
Brogard J.M., Kopferschmitt J., Arnaud J.P., Dorner M., La ViUaureix J., (1980): Antimicrobiol. Agents and Chemotherapy. Biliary Elimination of Mezlocillin: An Experimental and Clinical Study,18, 69–76.
Gundert-RemyU., Weber E., (1982): Eur. J. Pharmacol. Elimination of Azlocillin in Patients with Biliary t-tube Drainage, 435–439.
Brogard J.M., Jehl F., Arnaud J.P., Lévy P., Pealadan F., Blicklé J.F., Monteil H., (1985): Scweiz. med. Wschr. Ciprofloxacine: évaluation de son éliminations biliare chez l’homme,11, 448–453.
Zaslow J., Rosenthal A., (1954): Ann. Surg. The Excretion and Concentration of Terramycin in the Abnormal Human Biliary Tract,139, 478–483.
Rundle F.F., Cass M.H., Robson B., Middleton M., (1955): Surgery. Bile drainage after cholecystectomy in man, with some observations on biliary fistula,37, 903–910.
Meyers W.C. (1986): in Textbook of Surgery. The Liver. Anatomy and physiology, Ed: Sabiston D.C., WB Saunders Philadelphia, 1053–1068.
Phillip S.F., Summerskill W.H.J., (1966): Mayo Clin. Proc. Occlusion of the jejunum for intestinal perfusion in man,41, 224–231.
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Ryde, M., Gustavsson, S. Biliary excretion of Olsalazine sodium in humans. European Journal of Drug Metabolism and Pharmacokinetics 12, 17–24 (1987). https://doi.org/10.1007/BF03189857
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DOI: https://doi.org/10.1007/BF03189857