Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone

  • U. Täuber
  • K. Schröder
  • B. Düsterberg
  • H. Matthes
Original Papers


The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 ug testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56±2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.8±3.32%.


Testosterone testosterone-undecanoate absolute bioavailability oral administration 


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  1. 1.
    Cantrill I.A., Dewis P., Large D.M., Newman M. and Anderson D.C. (1984): Which testosterone replacement therapy ? Clin. Endocrin.,21, 97–107.CrossRefGoogle Scholar
  2. 2.
    Schürmeyer T. and Nieschlag E. (1984): Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivafy testosterone levels in normal man. Int. J. Androl.7, 181–187.CrossRefPubMedGoogle Scholar
  3. 3.
    Murad F. and Haynes R.C. (1980): Androgens and anabolic steroids in : Goodman and Gilmans, The Pharmacological Basis of Therapeutics 6. Ed. MacMillan Publ. Co. New York, Toronto,London, 1448–1465.Google Scholar
  4. 4.
    Dagett P.R., Wheeler M.J. and Naborro J.D.N. (1978): Oral testosterone, a reappraisal. Hormone Res.,9, 121–129.CrossRefGoogle Scholar
  5. 5.
    Nieschlag E., Mauss J., Coert A. and Kicovic P. (1975): Plasma androgen levels in men after oral administration of testosterone or testosterone-undecanoate. Acta Endocrinol.,79, 366–374.PubMedGoogle Scholar
  6. 6.
    Tamm J. (1967): Der Testosteronstoffwechsel beim Menschen. Dtsch. med. Wschr.,92, 2080–2086.PubMedGoogle Scholar
  7. 7.
    Nieschlag E., Cüppers H.J. and Wickings E.J. (1977): Influence of sex, testicular development and liver function on the bioavailability of oral testosterone. Europ. J. Clin. Invest.,7, 145–147.CrossRefPubMedGoogle Scholar
  8. 8.
    Southren A.K., Gordon G.G., Tochimoto S., Pinzon G., Lane D.R. and Stypulkowski W. (1967): Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men a n d women using a constant infusion procedure: Effect of time of day and plasma concentration on the metabolic clearance rate of testosterone. J. Clin. Endocr.,27, 686–694.CrossRefPubMedGoogle Scholar
  9. 9.
    Frey H., Aakwaag A., Saanum D. and Falich J. (1979): Bioavailability of oral testosterone in males. Eur. J. Clin. Pharmacol.,16, 345–349.CrossRefPubMedGoogle Scholar
  10. 10.
    Schürmeyer T., Wickings e.J., Freischem L.W. and Nieschlag E. (1983): Saliva and serum testosterone following oral testosterone-undecanoate administration in normal and hypogonadal man. Acta Endocrinol.,102, 456–462.PubMedGoogle Scholar
  11. 11.
    Horton T. and Tait J.F. (1966): Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible sites of conversion of testosterone. J. Clin. Invest.,45, 301–313.CrossRefPubMedGoogle Scholar
  12. 12.
    Coert A., Geelen J., de Vissier J. and van der Vies J. (1975): The Pharmacology and metabolism of testosterone-undecanoate (TU), a new orally active androgen. Acta Endocrinolgica,79, 789–800.Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • U. Täuber
    • 1
  • K. Schröder
    • 1
  • B. Düsterberg
    • 1
  • H. Matthes
    • 1
  1. 1.Research Laboratories, D. Pharmacokinetics ASchering AGBerlin 65

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