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Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone

  • U. Täuber
  • K. Schröder
  • B. Düsterberg
  • H. Matthes
Original Papers

Summary

The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 ug testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56±2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.8±3.32%.

Key-words

Testosterone testosterone-undecanoate absolute bioavailability oral administration 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • U. Täuber
    • 1
  • K. Schröder
    • 1
  • B. Düsterberg
    • 1
  • H. Matthes
    • 1
  1. 1.Research Laboratories, D. Pharmacokinetics ASchering AGBerlin 65

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