Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone
- 96 Downloads
The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 ug testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56±2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.8±3.32%.
Key-wordsTestosterone testosterone-undecanoate absolute bioavailability oral administration
Unable to display preview. Download preview PDF.
- 3.Murad F. and Haynes R.C. (1980): Androgens and anabolic steroids in : Goodman and Gilmans, The Pharmacological Basis of Therapeutics 6. Ed. MacMillan Publ. Co. New York, Toronto,London, 1448–1465.Google Scholar
- 8.Southren A.K., Gordon G.G., Tochimoto S., Pinzon G., Lane D.R. and Stypulkowski W. (1967): Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men a n d women using a constant infusion procedure: Effect of time of day and plasma concentration on the metabolic clearance rate of testosterone. J. Clin. Endocr.,27, 686–694.CrossRefPubMedGoogle Scholar
- 12.Coert A., Geelen J., de Vissier J. and van der Vies J. (1975): The Pharmacology and metabolism of testosterone-undecanoate (TU), a new orally active androgen. Acta Endocrinolgica,79, 789–800.Google Scholar