Summary
Trimethoprim (TMP) 10 mg.kg−1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 μg.kg−1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.
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References
Lapka R., Urbanová Z., Kobylka B., Rašková H., Vaněček J. and Polák L. (1978): Pharmacokinetics of sulfadimidine in normal and diarrheic calves. Drug Metab. Disp.,6, 637–639.
Sechserová M., Sechser T., Rašková H., Elis J., Vaněček J., Polák L., Matějovská D. and Raška K. (1979): Ontogenic Drug Studies in Calves. II. Changes in salicylate levels and metabolism in calves with diarrhoea. Arzneim.-Forsch.,29, 5, 804–807.
Rašková H., Lapka R., Langmeierová M., Urbanová Z., Černý J., Vaněček J., Kubiček A. and Polák L. (1980): Escherichia coli endotoxin and enterotoxin implication on pharmacokinetics of drugs, Natural Toxins pp. 369–376, Ed. D. Eaker and T. Wadström, Pergamon Press Oxford and New York.
Rašková H. and Mašek K. (1971): Streptococcal Toxins. In: Microbial Toxins, International Encyclopedia Pharmacology and Therapeutics, Sect. 7, Vol. 1, p. 39 (Rašková ed.), Oxford.
Rotta J. and Scheifer K.H. (1974): Pyrogenic activity of bacterial mucopeptides. J. Hyg. Microbiol., Immunol.,18, 50–59.
Heymer B. (1975): Biological Properties of the Peptidoglycan. Z. Immun. Forsch.,149, 245–257.
Krause M.R. and McCarty J.J. (1961): Studies on the chemical structure of the streptococcal cell walls. I. The identification of mucopeptide in the cell walls of groups A and A-variant streptococci. J. Exp. Med.,114, 127.
Schwartz D.E., Koechlin B.A. and Weinfeld R.E. (1969): Spectrofluorometric method for the determination of Trimethoprim in body fluids. Chemotherapy,14, 22–29.
Van Miert A.S.J.P.A.M., Van Gogh H. and Wit J.G. (1976): The influence of pyrogen induced fever on absorption of sulfa drugs. Vet. Ree,99, 480–481.
Ladefoged O. (1977): Pharmacokinetics of Trimethoprim in normal and febrile rabbits. Acta Pharmacol. Toxicol.,41, 507–514.
Lapka R., Langmeierová M., Vaněček J. and Rašková H. (1980): Changes of pharmacokinetics and metabolism of sulfadimidine in endotoxin pretreated rabbits. Arch. Toxicol. Suppl.,4, 325–327.
Lavický J., Čeleda L., Urbanová Z., Rašková H., Květina J., Vaněček J., Hofman J. and Kubiček A. (1984): Vliv endo-toxinu na hladiny rifampicinu v séru telat. Čas. lék. čes., 123,22, 681–682 (In Czech).
Mašek K., Rašková H. and Rotta J. (1968): The mechanism of the pyrogenic effect of streptococcus cell wall mucopeptide. J. Physiol.,192, 345–349.
Mašek K., Rašková H. and Rotta J. (1972): On the mechanism of fever caused by the mucopeptide of group A streptococcus. Naunyn-Schmiedebergs Arch. Pharmakol.,274, 138–145.
Van Miert A.S.J.P.A.M., De la Parra D.A. (1970): Inhibition of gastric emptying by endotoxin in conscious rats and modification of this response by drugs affecting the autonomic nervous system. Arch. Int. Pharmacodyn. Ther.,184, 27–33.
Lefebvre R., Čeleda L., Morávek J. Hofman J. and Rašková H. (1983): Influence of endotoxin on the pharmacokinetics of rifampicin in rabbits. Physiol. Bohemosl.,32, 381–384.
Mašek K., Paegelow I., Rašková H., Pávek K. and Rotta J. (1973): Hemodynamic effects of group A streptococcus mucopeptide. Proc. Soc. Exp. Biol. Med.,144, 1020–1024.
Lapka R., Čeleda L., Černý J., Sýkora Z., Urbanová Z, Rašková H., Vaněček J. and Kubiček A. (1980): Ontogenic changes of trimethoprim/sulfadiazine pharmacokinetics. Zbk, Pharm.,119, 1056–1059.
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Lavický, J., Černý, J., Čeleda, L. et al. Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan. European Journal of Drug Metabolism and Pharmacokinetics 11, 17–22 (1986). https://doi.org/10.1007/BF03189770
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DOI: https://doi.org/10.1007/BF03189770