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Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

  • J. Lavický
  • J. Černý
  • L. Čeleda
  • J. Rotta
  • J. Květina
  • H. RaŠková
  • A. Kubíček
Article

Summary

Trimethoprim (TMP) 10 mg.kg−1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 μg.kg−1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.

Key-words

Trimethoprim Peptidoglycan pharmacokinetics calves rabbits 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Lavický
    • 1
  • J. Černý
    • 2
  • L. Čeleda
    • 2
  • J. Rotta
    • 3
  • J. Květina
    • 1
  • H. RaŠková
    • 4
  • A. Kubíček
    • 4
  1. 1.Department of Pharmacology, Pharmaceutical FacultyCharles UniversityHradec Králové
  2. 2.Institute of Postgraduate Veterinary MedicineDukovany
  3. 3.Institute of Hygiene and EpidemiologyPrague
  4. 4.Czechoslovak Academy of SciencesPragueCzechoslovakia

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