Weibull function fits to pharmacokinetic data of ribavirin in man

Summary

Weibull function C=Bt^s−1exp(−λt^s) was used to describe plasma concentration-time data of ribavirin in 6 healthy subjects following an i.v. dose of 600 mg. A good fit was found in each of the subjects, where the coefficients of determination r² were > 0.99. The parameters estimated were as follows: B, 5.90 ± 1.86 μg.h^1−s; λ, 0.607 ± 0.156 h^−s; and s, 0.339 ± 0.085, respectively. The results were compared with those by triexponential function. By providing lower values of AIC and SD, as well as higher values of r², the Weibull function proved to be superior to triexponential function for data of 3 subjects. These results indicated that both Weibull function and triexponential function provided a good fit of plasma concentration-time data of ribavirin in man following an i.v. dose.