Kinetics of ketamine and its metabolites in rabbits with normal and impaired renal function
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The plasma levels of ketamine, an anaesthetic, a n d its metabolites were studied in 10 rabbits with normal renal function a n d in 9 rabbits with varying degrees of experimentally induced renal impairment. All the animals received a single bolus type i.v. dose of 10 mg/kg of the drug. The results obtained reveal an apparent inhibition of the biotransformation of ketamine in rabbits with renal impairment in which the drug is accumulated. The plasma half-life of ketamine ranged from 0.74 h in rabbits with normal renal function to 2.6 h in the animals with severe renal impairment. The plasma levels of norketamine (metabolite I) did not alter significantly in states of renal impairment. However, the kinetics of t h e other metabolite (II), dehydronorketamine, did change significantly in renal impairment, due to its high renal excretion capacity.
Key-wordsKetamine pharmacokinetics metabolism renal impairment
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- 2.Wieber J., Gugler R., Hengstuman J.H. and Dengler M.J. (1975): Pharmacokinetic of ketamine in man. Anaesthetist,24, 260–263.Google Scholar
- 4.Steimberg P. and Idwall J. (1981): Does ketamine metabolite II exist in vivo? British Journal of Anaesthesia,53, 778.Google Scholar
- 5.Pedraz J.L., Marino E.L. and Dominguez-Gil A. (1983): Quantitative determination of ketamine and its metabolites in man by gas-liquid chromatography. II Farmaco,38, 209–218.Google Scholar
- 8.Nemeth I. and Szeleczki T. (1980): Increased D-glucaric acid excretion in children with renal disease. International Journal of Clinical Pharmacology and Toxicology,18, 357–360.Google Scholar