Effect of clozapine and molindone on plasma and brain levels of mescaline in mice

  • Nandkumar S. Shah
  • Om Datt Gulati
Original Papers


Levels of unchanged mescaline were examined in the plasma and brain of albino Swiss-Webster mice pretreated with various doses of either clozapine or molindone. In clozapine treated mice, the mescaline levels were statistically significantly higher at 2 and 3h with 7.5 and 15.0 mg/kg and at 1, 2 and 3 h with 30 mg/kg. Molindone at 4.0 and 8.0 mg/kg produced no significant effect ; at 16.0 and 48.0 mg/kg, the levels were significantly higher at 1 and 2 h. Elevated brain levels of mescaline by clozapine and molindone indicate an adverse metabolic interaction between a hallucinogen and drugs that are commonly used to treat mescaline-induced psychosis.

Key words

Clozapine molindone mescaline mice plasma level brain level 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Nandkumar S. Shah
    • 1
  • Om Datt Gulati
    • 2
  1. 1.Ensor Foundation Research LaboratoryWilliam S. Hall Psychiatric InstituteColumbiaUSA
  2. 2.Department of PharmacologyBaroda Medical CollegeBarodaIndia

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