The metabolism of nicotine-Δ1′(5′)-iminium ion,in vivo andin vitro
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Nicotine-Δ1′(5′)-iminium ion, either as the diperchlorate or the hydrochloride, is rapidly converted into cotinine by a hepatic cytoplasmic enzyme. Incubations in an atmosphere of nitrogen indicated that the oxygen incorporated into cotinine is derived from water.
Following the intraperitoneal administration of nicotine-Δ1′(5′)-iminium ion to guinea pigs or rats, cotinine, and nicotine1′-N-oxide were found in the urine.
The results support the idea that nicotine-Δ1′(5′)-iminium ion is an intermediate in the metabolic conversion of nicotine to cotinine.
Key wordsmetabolism in vivo vitro nicotine-Δ1′(5′)-iminium ion
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