The metabolism of nicotine-Δ1′(5′)-iminium ion,in vivo andin vitro

  • J. W. Gorrod
  • A. R. Hibberd


Nicotine-Δ1′(5′)-iminium ion, either as the diperchlorate or the hydrochloride, is rapidly converted into cotinine by a hepatic cytoplasmic enzyme. Incubations in an atmosphere of nitrogen indicated that the oxygen incorporated into cotinine is derived from water.

Following the intraperitoneal administration of nicotine-Δ1′(5′)-iminium ion to guinea pigs or rats, cotinine, and nicotine1′-N-oxide were found in the urine.

The results support the idea that nicotine-Δ1′(5′)-iminium ion is an intermediate in the metabolic conversion of nicotine to cotinine.

Key words

metabolism in vivo vitro nicotine-Δ1′(5′)-iminium ion 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. W. Gorrod
    • 1
  • A. R. Hibberd
    • 1
  1. 1.Department of Pharmacy, Chelsea CollegeUniversity of LondonLondonU.K.

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