Inhibition of the cytochrome P-450 multifunctional oxidase by N-propargyl analogs of SKF-525A and acetylmethadol

  • J. L. Kraus
  • J. J. Yaouanc
Original Papers


New N-propargyl analogs of SKF-525A and acetyl methadol were tested for their inhibitory potency toward P-450 multifunctional oxidase. Metabolism of these analogs appears to be different from the metabolism of SKF-525A itself; no N-dealkylated species were detected, — in vitro N-demethylation of aminopyrine and spectrofluorometric measurements support the hypothesis of an interaction between the hepatic flavo-protein and the acetylenic function of the inhibitors.


Cytochrome P-450 N-propargyl analogs Flavoprotein 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. L. Kraus
    • 1
  • J. J. Yaouanc
    • 1
  1. 1.Laboratoire de chimie hétéro-organiqueFaculté des Sciences & TechniquesBREST-CédexFrance

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