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The fate of Ticlopidine in the organism II. — Distribution and elimination of Ticlopidine14C after a single oral administration in the rat

  • Philippe Godard
  • Roland Zini
  • Agnès Metay
  • Jean -Paul Tillement
Original Papers

Summary

In the Rat, distribution and elimination of Ticlopidine C14 after a single oral dose of 25 mg/kg were studied and compared with that observed after a single intravenous injection of the same dose.

The plasma decreases of total radioactivity were found to be identical regardless of administration route, indicating almost complete absorption of the labelled molecule.

The elimination half-life, which was 1.56 ± 0.08 days, was equivalent to the half-life measured after intravenous injection, and no difference in tissues distribution was observed. As in the case of intravenous injection, the radioactivity was eliminated principally in the feces and only to a slight degree in the urine.

Key-words

Distribution Elimination Ticlopidine14Rat 

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References

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Philippe Godard
    • 1
    • 2
  • Roland Zini
    • 1
    • 2
  • Agnès Metay
    • 1
    • 2
  • Jean -Paul Tillement
    • 1
    • 2
  1. 1.Département de PharmacologieFaculté de Midécine de Paris XIICreteilFrance
  2. 2.Laboratoire de Pharmacologie et de Physiologie, Département de Biologie appliquée, InstitutUniversitaire de TechnologieCréteilFrance

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