The metabolism of saddamine in man: The fate of the benzylamine moiety of saddamine

  • M. R. Al-Ani
  • S. G. Wood
  • A. Lawson
Original Papers


The metabolism of14C-saddamine radiolabelled in the benzylamine moiety has been investigated in man after oral administration.14C-Hippuric acid was found to be the only radiolabelled urinary metabolite, the overall amount of which was equivalent to over 95% of the dose. The time taken for elimination of 50% of the dose in the urine was approximately five hours and the corresponding value for14C-benzylamine hydrochloride was less than one hour. Department of Biochemistry, College of

Key words

14C-Saddamine 14C-benzylamine hydrochloride hippuric acid urinary excretion man 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. (1).
    Lawson A. and Al-Sayyab A.F. (1976): Pharmaceutical products containing Schiff bases. Brit. Pat. Appl. No. 19157/74, Chem. Abs.,84, 70.Google Scholar
  2. (2).
    Levy G. and Amsel L.P. (1966): Kinetics of competitive inhibition of salicylic acid conjugation with glycine in man. Biochem. Pharmacol.,15, 1033–1038.CrossRefPubMedGoogle Scholar
  3. (3).
    Dry T.J., Butt H.R. and Scheifley C.H. (1946): The effect of oral administration of para-aminobenzoic acid on the concentration of salicylates in the blood. Proc. Mayo Clin.,21, 497–501.PubMedGoogle Scholar
  4. (4).
    Salassa R.M., Bollman J.L. and Dry T.J. (1948): The effect of para-aminobenzoic acid on the metabolism and excretion of salicylate. J. Lab. Clin. Med.,33, 1393–1401.PubMedGoogle Scholar
  5. (5).
    Schmiedeberg O. (1877): Ueber das Verhaltniss des Ammoniaks und der primaren Monaminbasen zur Harnstoffbildung in Thierkorper. Archiv. fur experiment. Pathol, u. Pharmakol.,8, 1–14.CrossRefGoogle Scholar
  6. (6).
    Mosso U. (1890): Quantitative Untersuchungen uber die Ausscheidung der Umwandlungsproducte des Benzylamins aus dem fhierischen Organisms. Archiv. fur experiment. Pathol, u. Pharmakol.,26, 267–278.CrossRefGoogle Scholar
  7. (7).
    Imai T. (1924): Verber das Verhalten des Benzylamins im Tierkoerper. Acta Scholae Med. Univ. in Kyoto,6, 415–419.Google Scholar
  8. (8).
    Blaschko H., Richter D. and Schlossmann H. (1937): The oxidation of adrenaline and other amines. Biochem. J.,31, 2187–2196.PubMedGoogle Scholar
  9. (9).
    Richter D. (1937): Adrenaline and amine oxidase. Biochem. J.,31, 2022–2028.PubMedGoogle Scholar
  10. (10).
    Richter D. (1938): Elimination of amines in man. Biochem. J.,32, 1763–1769.PubMedGoogle Scholar
  11. (11).
    Wood S.G., Al-Ani M.R. and Lawson A. (1978): Hippuric acid excretion after benzylamine ingestion in man. British J. Ind. Med.,35, 230–231.Google Scholar
  12. (12).
    Al-Ani M.R., Wood S.G. and Lawson A. (1978): Comparison of the major urinary metabolites of Saddamine and aspirin using thin-layer chromatography. J. Chromatog.,166, 626–631.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • M. R. Al-Ani
    • 1
  • S. G. Wood
    • 1
  • A. Lawson
    • 1
  1. 1.Department of BiochemistryCharing Cross Hospital Medical SchoolLondonEngland

Personalised recommendations