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The effect of prednisolone on the metabolic handling of antipyrine

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European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

Antipyrine studies were conducted in patients with rheumatoid arthritis to assess the enzyme inducing potential of long-term therapy with prednisolone. No significant difference in any pharmacokinetic parameter for antipyrine between prednisolone-treated and control subjects was observed. In addition, total body water was similar in both groups suggesting that there is no retention due to prednisolone treatment.

Possible explanations are discussed.

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Authors and Affiliations

  1. Clinical Pharmacology Unit (Rheumatism Research), Royal Bath Hospital, Cornwall Road, HG1 2PS, Harrogate, North Yorkshire, England

    W. W. Downie, V. M. Rhind, J. R. Lowe, J. S. Dixon & M. E. Pickup

  2. Rheumatism Research Unit, University Department of Medicine, the University of Leeds, England

    P. A. Leatham & V. Wright

Authors
  1. W. W. Downie
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  2. V. M. Rhind
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  3. J. R. Lowe
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  4. P. A. Leatham
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  5. J. S. Dixon
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  6. V. Wright
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  7. M. E. Pickup
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Downie, W.W., Rhind, V.M., Lowe, J.R. et al. The effect of prednisolone on the metabolic handling of antipyrine. European Journal of Drug Metabolism and Pharmacokinetics 3, 99–101 (1978). https://doi.org/10.1007/BF03189377

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  • DOI: https://doi.org/10.1007/BF03189377

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