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The effect of prednisolone on the metabolic handling of antipyrine

  • W. W. Downie
  • V. M. Rhind
  • J. R. Lowe
  • P. A. Leatham
  • J. S. Dixon
  • V. Wright
  • M. E. Pickup
Original Papers

Summary

Antipyrine studies were conducted in patients with rheumatoid arthritis to assess the enzyme inducing potential of long-term therapy with prednisolone. No significant difference in any pharmacokinetic parameter for antipyrine between prednisolone-treated and control subjects was observed. In addition, total body water was similar in both groups suggesting that there is no retention due to prednisolone treatment.

Possible explanations are discussed.

Keywords

Prednisolone antipyrine body water 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • W. W. Downie
    • 1
  • V. M. Rhind
    • 1
  • J. R. Lowe
    • 1
  • P. A. Leatham
    • 2
  • J. S. Dixon
    • 1
  • V. Wright
    • 2
  • M. E. Pickup
    • 1
  1. 1.Clinical Pharmacology Unit (Rheumatism Research)Royal Bath HospitalHarrogate, North YorkshireEngland
  2. 2.Rheumatism Research Unit, University Department of Medicinethe University of LeedsEngland

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