Pharmacokinetics and disposition of orally administered [2,3-14C] succinimide in the rat
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The absorption, distribution, and elimination of radioactivity after the oral administration of14C-labelled succinimide has been investigated at three dosage levels (0.09, 1.0 and 2.0 g/kg). A comparison was made of the blood concentration of radioactivity after the intraperitoneal and oral administration of 0.5 g/kg of succinimide. The pharmacokinetics of orally administered succinimide have been fitted to a one-compartment open model. Maximum blood concentrations were seen after about 2 h. Absorption and elimination were faster after dosage at 0.09 g/kg than after 1.0 and 2.0 g/kg. Succinimide appeared to be well absorbed, and was evenly distributed throughout the body. About 70% of an administered dose of 1.0 g/kg was eliminated within 32 h; 50% in the urine, 4% in the faeces, and 17% as14CO2 in the expired air. Approximately 90% of the radioactivity in the urine (0–24 h) was succinimide.
Key wordssuccinimide pharmacokinetics elimination tissue distribution
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