Comparative evaluation of the hypotensive activity of two major metabolites of hydralazine (1-hydrazinophthalazine)
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Triazolophthalazine (TP) and hydralazine-acetonide (HA) are important hydralazine metabolites in rat. Conscious rats chronically implanted with aortic and jugular venous catheters, were injected with these metabolites while blood pressure was recorded. TP was inert but HA produced dose-dependent hypotensive effects. HA may contribute to the unexplained, prolonged hypotensive effects of hydralazine.
Key-wordsHydralazine Hydralazine acetonide Triazolophthalazine in vivo comparison
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