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Comparative evaluation of the hypotensive activity of two major metabolites of hydralazine (1-hydrazinophthalazine)

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Summary

Triazolophthalazine (TP) and hydralazine-acetonide (HA) are important hydralazine metabolites in rat. Conscious rats chronically implanted with aortic and jugular venous catheters, were injected with these metabolites while blood pressure was recorded. TP was inert but HA produced dose-dependent hypotensive effects. HA may contribute to the unexplained, prolonged hypotensive effects of hydralazine.

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Authors and Affiliations

  1. Division of Clinical Pharmacology and Hypertension, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, U.S.A.

    A. J. Mclean, K. D. Haegele Ph.D., P. Du Souich & J. L. Mcnay

  2. Division of Clinical Pharmacology and Hypertension, Department of Pharmacology, The University of Texas Health Science Center, 78284, San Antonio, Texas, U.S.A.

    A. J. Mclean, K. D. Haegele Ph.D., P. Du Souich & J. L. Mcnay

  3. Division of Clinical Pharmacology and Hypertension, Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas, U.S.A.

    A. J. Mclean, K. D. Haegele Ph.D., P. Du Souich & J. L. Mcnay

  4. Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio, Texas, U.S.A.

    A. J. Mclean, K. D. Haegele Ph.D., P. Du Souich & J. L. Mcnay

Authors
  1. A. J. Mclean
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  2. K. D. Haegele Ph.D.
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  3. P. Du Souich
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  4. J. L. Mcnay
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Mclean, A.J., Haegele, K.D., Souich, P.D. et al. Comparative evaluation of the hypotensive activity of two major metabolites of hydralazine (1-hydrazinophthalazine). European Journal of Drug Metabolism and Pharmacokinetics 2, 17–20 (1977). https://doi.org/10.1007/BF03189312

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  • DOI: https://doi.org/10.1007/BF03189312

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