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Biotransformation of pethidine: A comparative study of 24 h urine in three ethnic groups

  • I. T. Houghton
  • K. Chan
  • Y. -C. Wong
  • D. H. -Y. Leung
  • C. S. T. Aun
Article

Summary

219 surgical patients of either Caucasian, Chinese or Nepalese origin were given pethidine 1 mg/kg by intramuscular injection as pre-operative medication. Urine was collected for 24 h and analysed for pethidine, pethidinic acid, pethidinic acid conjugates, norpethidine, norpethidinic acid, and norpethidinic acid conjugates. The mean proportion of the percentage of metabolites attributable to oxidative demethylation, hydrolysis and conjugation was almost identical in each ethnic group (P>0.2). It was concluded that there were no differences in the metabolic variability of the biotransformation of pethidine in Asians and Caucasians in whom the urine pH had not been acidified.

Keywords

Pethidine ethnic groups Caucasians Chinese Nepalese metabolism polymorphism 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • I. T. Houghton
    • 1
    • 2
  • K. Chan
    • 3
  • Y. -C. Wong
    • 4
  • D. H. -Y. Leung
    • 5
  • C. S. T. Aun
    • 6
  1. 1.Department of Anaesthesia and ResuscitationBritish Military HospitalHong KongChina
  2. 2.Department of Anaesthesia and Intensive CareChinese University of Hong KongHong KongChina
  3. 3.Department of PharmacologyChinese University of Hong KongHong KongChina
  4. 4.Government Analytical LaboratoryRoyal Hong Kong PoliceHong KongChina
  5. 5.Faculty of MedicineChinese University of Hong KongHong KongChina
  6. 6.Department of Anaesthesia and Intensive CareChinese University of Hong KongHong KongChina

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