Mass spectral investigation of the metabolites of lorcainide in man.

  • W. F. J. Lauwers
  • W. E. G. Meuldermans
  • J. O. Bracke


[3H] Lorcainide hydrochloride was administered orally to healthy male volunteers. About 97 % of the total radioactivity was excreted in the urine and faeces within four days of its administration. The metabolites were purified by adsorption chromatography, liquid-liquid extraction, thin layer chromatography or by gas chromatography-mass spectrometry after silylation of the samples. When there was a sufficient amount available, the samples were submitted to a nuclear magnetic resonance analysis. The results were confirmed by comparison of spectral data obtained from the reference compounds. The major metabolites of lorcainide were formed by aromatic hydroxylation,O-methylation and oxidativeN-dealkylation. The urinary phenolic metabolites were present both as free aglycons and conjugates.

Key words

Lorcainide Mass Spectrometry Drug Metabolism 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • W. F. J. Lauwers
    • 2
    • 1
  • W. E. G. Meuldermans
    • 2
  • J. O. Bracke
    • 2
  1. 1.Department of Drug Metabolism and PharmacokineticsResearch laboratories, Janssen PharmaceuticaBeerseBelgium
  2. 2.Department of Analytical ResearchJanssen PharmaceuticaBeerseBelgium

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