Summary
[3H] Lorcainide hydrochloride was administered orally to healthy male volunteers. About 97 % of the total radioactivity was excreted in the urine and faeces within four days of its administration. The metabolites were purified by adsorption chromatography, liquid-liquid extraction, thin layer chromatography or by gas chromatography-mass spectrometry after silylation of the samples. When there was a sufficient amount available, the samples were submitted to a nuclear magnetic resonance analysis. The results were confirmed by comparison of spectral data obtained from the reference compounds. The major metabolites of lorcainide were formed by aromatic hydroxylation,O-methylation and oxidativeN-dealkylation. The urinary phenolic metabolites were present both as free aglycons and conjugates.
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Lauwers, W.F.J., Meuldermans, W.E.G. & Bracke, J.O. Mass spectral investigation of the metabolites of lorcainide in man.. European Journal of Drug Metabolism and Pharmacokinetics 8, 351–362 (1983). https://doi.org/10.1007/BF03188767
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DOI: https://doi.org/10.1007/BF03188767