Advertisement

Annals of Vascular Surgery

, Volume 2, Issue 3, pp 215–219 | Cite as

Indium-111 platelet scintigraphy in carotid disease

  • Alain Branchereau
  • Pierre-Jean Bernard
  • Godefroy Ciosi
  • Maurice Bazan
  • Catherine de Laforte
  • Antoine Elias
  • Jean-Louis Bouvier
Original Papers from the French Vascular Surgical Society
  • 3 Downloads

Abstract

Forty-five patients (35 men, 10 women) undergoing carotid surgery had Indium-111 platelet scintigraphy as part of their preoperative work-up. Imaging was performed within three hours after injection of the lndium-111. A second series of views was obtained 24 hours later and repeated at 24 hour intervals for two days. Of 54 scintigrams, 22 were positive and 32 negative. Positive results were defined as a twofold or more increase In local activity on a visualized carotid after 24 hours. The sensitivity of the method was 41%, intraoperatively, and the specificity, 100%. The low sensitivity places this method behind sonography and duplexscanning for screening patients for surgery. We believe that indications for platelet scintigraphy are limited to: 1. Repeated transient ischemic attacks in the same territory with minimal lesions on arteriography and non-homogeneous plaque on duplex scan; 2. Symptomatic patients being treated medically as a possible argument for surgery; 3. Determining therapeutic policy for patients having experienced a transient ischemic attack with a coexisting intracardiac thrombus.

Key Words

Indium111 platelet scintigraphy carotid disease transient ischemic attack 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    FLANIGAN DP, SHULER JJ, VOGEL M, BOROZAN PG, GRAY B, SOBINSKY KR. The role of carotid duplex scanning in surgical decision making.J Vasc Surg 1985;2:15–25.CrossRefPubMedGoogle Scholar
  2. 2.
    EZEKOWITZ MD, WILSON DA, SMITH EO, BUROW RD, HARRISON Jr LH, PARKER DE, ELKINS RC, PEYTON M, TAYLOR FB. Comparison of Indium-1ll platelet scintigraphy and two-dimensional echocardiography in the diagnosis of left ventricular thrombi.N Engl J Med 1982;306:1509–1513.PubMedGoogle Scholar
  3. 3.
    BENICHOU M, BERNARD PJ, SARRAT P, SERRA-DIMIGNI A. Thrombi intra cardiaques. Detection par gamma scintigraphic aux plaquettes marquees a l’Indium-lll.Nouv Presse Med 1982;11:1414–1415.PubMedGoogle Scholar
  4. 4.
    BENICHOU M, BERNARD PJ, SARRAT P, LARBI MB, BAZAN M, SANDALIAN A, SERRADIMIGNI A. La detection des caillots infra cardiaques par la scintigraphic aux plaquettes marquees a l’Indium-lll. Confrontation avec l’echographie bidimensionelle et la scanographie cardiaque.Arch Mai Coeur 1984;77:1054–1063.Google Scholar
  5. 5.
    PERNARD PJ, BRANCHEREAU A, DEVIN R. Scintigraphic aux plaquettes marquees a l’Indium-lll. Apport au diagnostic des embolies d’origine arterielle.Chirurgie 1984;110:105–115.Google Scholar
  6. 6.
    BERNARD PJ, BRANCHEREAU A, MERCIER C, KASBARIAN M, BAZAN M. Place de la scintigraphic aux plaquettes marquees a l’Indium-111 dans la decision opératoire en chirurgie vasculaire.J Biophys Med Nucl 1984;8:177–179.Google Scholar
  7. 7.
    BERNARD PJ, BRANCHEREAU A. Individuazione e controllo delle thrombosi arteriose mediante le piastrine marcate all’indio111. In: PIETRI P, PANCRAZIO F. (eds) Le Protesi Vascolari. Turin: Minerva Medica, 1987; pp 311–316.Google Scholar
  8. 8.
    BERNARD PJ, BAZAN M, DE LAFORTE C. Labeled platelets in the detection of the thrombotic process.Nucl Med Biol 1986; 13:165–171.Google Scholar
  9. 9.
    POWERS WJ.111In platelet scintigraphy: carotid atherosclerosis and stroke.J Nucl Med 1984;25:626–629.PubMedGoogle Scholar
  10. 10.
    DAVIS HH, SIEGEL BA, SHERMANN LA, HEATON WA, NAIDICH TP, JOIST JH, WELCH MJ. Scintigraphic detection of carotid atherosclerosis with indium111 — labeled autologous platelets.Circulation 1980;61:982–988.PubMedGoogle Scholar
  11. 11.
    GOLDMAN M, MC COLLUM CN. Platelet involvement in carotid disease. In: GREENHALGH RM, ROSE FC (eds). Progress in stroke research 2. London: Pitman, 1983; 13–26.Google Scholar
  12. 12.
    GOLDMAN M, LEUNG JO, AUKLAND A. 111-Indium platelet imaging, doppler spectral analysis and angiography compared in patients with transient cerebral ischemia.Stroke 1983;14:752–756.PubMedGoogle Scholar
  13. 13.
    BERNARD PJ, SERRADIMIGNI A. Detection et surveillance des thromboses cardiaques et arterielles par les plaquettes marqueesa l’Indium-lll.Bull Acad Natle Med 1985;169:1183–1190.Google Scholar
  14. 14.
    ISAKA Y, KIMURA K, YONEDA S, KUSUNOKI M, ETANI H, UYAMA O, TSUDA Y, ABE H. Platelet accumulation in carotid atherosclerotic lesions: semiquantitative analysis with Indium-111 platelets and Technetium 99 m human serum albumin.J Nucl Med 1984;25:256–563.Google Scholar
  15. 15.
    15. FDA advisory committee finds In.111 oxine low risk.J Nucl Med (Newsline) 1984;25:122.Google Scholar
  16. 16.
    THOMAS J, OTIS SM, RUSH MM, ZYROFF J, DILLEY RB, BERNSTEIN EF. The contribution of spectral analysis to the diagnosis of carotid artery disease.J Vasc Surg 1985;2:270–277.CrossRefPubMedGoogle Scholar
  17. 17.
    BERNARD P, BENICHOU M, COORNAERT S, et al. Detection of intra-cardiac thrombi by 111 Indium oxine autologous platelets: role of heparin therapy. In: Raynaud C. (ed) Nuclear medicine and biology proceedings of the third world congress of nuclear medicine and biology. Paris: Pergamon Press, 1982 pp 2381–2384.Google Scholar

Copyright information

© Annals of Vascular Surgery Inc. 1988

Authors and Affiliations

  • Alain Branchereau
    • 1
  • Pierre-Jean Bernard
    • 1
    • 2
  • Godefroy Ciosi
    • 1
    • 2
  • Maurice Bazan
    • 1
    • 2
  • Catherine de Laforte
    • 1
    • 2
  • Antoine Elias
    • 1
    • 2
  • Jean-Louis Bouvier
    • 1
    • 2
  1. 1.Service de Chirurgie VasculaireHôpital de La TimoneMarseille Cedex 05France
  2. 2.Service d’Hématologie et Cardiologie IsotopiqueHôpital de La TimoneMarseille Cedex 05France

Personalised recommendations