Monoclonal antibody immunoassay in the study of thrombogenicity of preclotted and gelatin-impregnated aortic prostheses
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Peripheral Vascular Surgery Unit and University Department of Medicine (Hemostasis and Thrombosis Research Unit), Glasgow Royal Infirmary 16 Alexandra Parade, Glasgow, Scotland. The Dimertest Enzyme Immunoassay has been used to compare the degree of thrombogenicity of the standard knitted Dacron prosthesis (n = 10) and the gelatin-impregnated Dacron prosthesis (n = 10) after infrarenal aortic reconstruction. After surgery there was a similar rise in cross-linked fibrin degradation products with both types of prostheses. Although on the third day the D-Dimer level in the gelatin-impregnated prosthesis was lower, there was no significant difference in the D-Dimer level at six weeks. This suggests that the potential risk of thrombogenicity in the gelatin-impregnated prosthesis is similar to the standard preclotted type.
Key WordsThrombogenicity vascular prosthesis fibrin degradation products Dimertest Immunoassay
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