Skip to main content
SpringerLink
Log in

Monoclonal antibody immunoassay in the study of thrombogenicity of preclotted and gelatin-impregnated aortic prostheses

  • Original Articles
  • Published:
Annals of Vascular Surgery

Abstract

Peripheral Vascular Surgery Unit and University Department of Medicine (Hemostasis and Thrombosis Research Unit), Glasgow Royal Infirmary 16 Alexandra Parade, Glasgow, Scotland. The Dimertest Enzyme Immunoassay has been used to compare the degree of thrombogenicity of the standard knitted Dacron prosthesis (n = 10) and the gelatin-impregnated Dacron prosthesis (n = 10) after infrarenal aortic reconstruction. After surgery there was a similar rise in cross-linked fibrin degradation products with both types of prostheses. Although on the third day the D-Dimer level in the gelatin-impregnated prosthesis was lower, there was no significant difference in the D-Dimer level at six weeks. This suggests that the potential risk of thrombogenicity in the gelatin-impregnated prosthesis is similar to the standard preclotted type.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. RHODES RS, HUTTON MC, LALKA SG. Reoperation for intra-abdominal vascular disease. In: FRY DE (ed). Reoperative surgery of the abdomen. New York: Marcel Dekker, 1986; 152–247.

    Google Scholar 

  2. NEVELSTEEN A, SUY R, DAEMEN W, BOEL A, STALPAERT G. Aortofemoral grafting: factors influencing late results.Surgery 1980:88:642–653.

    CAS  PubMed  Google Scholar 

  3. ELMS MJ, BUNCE IH, BUNDESEN PG, DBRYLATT DB, WEBBER AJ, MASCI PP, WHITAKER AN. Measurement of crosslinked fibrin degradation products. An immunoassay using monoclonal antibodies.Thromb Haemostus 1983;50:591–594.

    CAS  Google Scholar 

  4. WHITAKER AN, ELMS MJ, MASCI PP, BUNZESEN PG, DBRYLATT DB, WEBBER AJ, BUNCE IH. Measurements of crosslinked fibrin derivatives in plasma: an immunoassay using monoclonal antibodies.Am J Clin Patho 1984;57: 882–887.

    Article  Google Scholar 

  5. ROWBOTHAN BJ, CARROLL P, WHITAKER AN. Measurement of crosslinked fibrin degradation products. An immunoassay using monoclonal antibodies.Thromb Haemostus 1983:50: 591–594.

    Google Scholar 

  6. WHITEHOUSE WM, ZELENOCK GB, WAKEFIELD TW. Functional assessment of- implanted vascular grafts utilizing radionuclide imaging. In: STANLEY JC, (eds). Biological and synthetic vascular prostheses. New York: Grune and Stratton, 1982;153–247.

    Google Scholar 

  7. GAFFNEY PJ. The occurrence and clinical relevance of fibrin fragments in blood.Ann NY Acad Sci 1983;408: 407–4355.

    Article  CAS  PubMed  Google Scholar 

  8. WHITAKER AN, MASCI PP, ROWBOTHAN BJ, CARROLL P, REASBECK P, GUERRINI SM, McCASSREY J, LEE K, ELMS MJ, GUNT D, WEBBER AJ, Reit. Applications of plasma assays of crosslinked fibrin degradation products (XLFDP) and the diagnosis of thrombo-embolic disease. In: Lowe GDO, et al (eds). Fibrinogen 2: biochemistry, physiology and clinical relevance. Amsterdam: Elsevier Science Publishers BV, 1987;205–208.

    Google Scholar 

  9. NIEUWENHUIZEN W. Plasma assays of fibrinogen/fibrin degradation products and their clinical relevance. In: LOWE GDO, NIEUWENHUIZEN W. (eds). Fibrinogen 2: biochemistry, physiology and clinical relevance. Amsterdam: Elsevier Science Publishers BV, 1987;173–179.

    Google Scholar 

  10. DRURY JK, ASHTON TR, CUNNINGHAM JD, MAINI R, POLLOCK JG. Experimental and clinical experience with a gelatin-impregnated Dacron prosthesis.Ann Vasc Surg 1987;1:542–547.

    Article  CAS  PubMed  Google Scholar 

  11. McCOLLUM CN, KESTER RC, RAJAH SM, LEAROYD P, PEPPER N. Arterial graft maturation: the duration of thrombotic activity in Dacron aorto-bifemoral grafts measured by platelet and fibrinogen kinetics.Br J Surg 1982;68:61–64.

    Article  Google Scholar 

  12. DeBAKEY ME, JORDAN GL, BEALL AG, NEVEL-STEEN A, SUY R, DAENEN W, BOEL A, STALPAERT G. Basic biologic reactions to vascular graft and prosthesis.Surg Clin North Am 1965;45:477–496.

    CAS  PubMed  Google Scholar 

  13. YATES SG, BARROS D’SA AAB, BERGER K, FERNANDEZ LG, WOOD SJ, RITTENHOUSE EA, MANSS-FIELD PB, SAUVAGE LR. The preclotting of porous arterial prostheses.Ann Surg 1978;188:611–622.

    Article  CAS  PubMed  Google Scholar 

  14. BIBBY SR, CROW MJ, SHEEHAM SJ. Should preclotted Dacron grafts still be used?Br J Surg (in press).

Download references

Author information

Authors and Affiliations

  1. Peripheral Vascular Surgery Unit, Glasgow Royal Infirmary, 16 Alexandra Parade, Glasgow, Scotland

    H. A. Zahrani FRCS, R. J. Cuschieri ChM, FRCS, G. D. O. Lowe MD, FRCP, J. T. Douglas PhD & J. G. Pollock FRCS (Consultant Vascular Surgeon)

  2. University Department of Medicine (Hemostasis and Thrombosis Research Unit), Glasgow Royal Infirmary, Glasgow, Scotland

    H. A. Zahrani FRCS, R. J. Cuschieri ChM, FRCS, G. D. O. Lowe MD, FRCP, J. T. Douglas PhD & J. G. Pollock FRCS (Consultant Vascular Surgeon)

Authors
  1. H. A. Zahrani FRCS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. J. Cuschieri ChM, FRCS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. D. O. Lowe MD, FRCP
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. T. Douglas PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. G. Pollock FRCS
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Zahrani, H.A., Cuschieri, R.J., Lowe, G.D.O. et al. Monoclonal antibody immunoassay in the study of thrombogenicity of preclotted and gelatin-impregnated aortic prostheses. Annals of Vascular Surgery 3, 248–250 (1989). https://doi.org/10.1007/BF03187403

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03187403

Key Words

Search

Navigation