Chinese Science Bulletin

, Volume 46, Issue 3, pp 184–188 | Cite as

Roles of histones and nucleosomes in gene transcription

  • Baiqu Huang
  • Qinhua Zeng
  • Xiaohui Bi
  • Yuhong Wang
  • Yuxin Li


This article reviews the latest research developments in the field of eukaryotic gene regulation by the structural alterations of chromatin and nucleosomes. The following issues are briefly addressed: (i) nucleosome and histone modifications by both the ATP-dependent remodeling complexes and the histone acetyltransferases and their roles in gene activation; (ii) competitive binding of histones and transcription factors on gene promoters, and transcription repression by nucleosomes; and (iii) influences of linker histone H1 on gene regulation. Meanwhile, the significance and impact of these new research progresses, as well as issues worthwhile for further study are commented.


histories nucleosome chromatin remoddeling gene transcription 


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Copyright information

© Science in China Press 2001

Authors and Affiliations

  • Baiqu Huang
    • 1
  • Qinhua Zeng
    • 1
  • Xiaohui Bi
    • 1
  • Yuhong Wang
    • 1
  • Yuxin Li
    • 1
  1. 1.Institute of Genetics and CytologyNortheast Normal UniversityChangchunChina

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