Chinese Science Bulletin

, Volume 48, Issue 8, pp 777–780 | Cite as

A novel cancer imaging method using chemiluminescence-mediated sonosensitization

  • Yonghong He
  • Da Xing
  • Juan Wang


In this paper, we introduce a novel method named chemiluminescence mediated sono dynamic diagnosis (SDD), which is designed as follows: sonosensitizer is used to localize the cancer tissue, and is sonosensitized by the ultrasound field to produce oxygen free radicals. Then, another agent, FCLA (fluoresceinyl cypridina luciferin analog), reacts with1O2 to efficiently transform the chemical energy of1O2 to photons, thus a strong chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of chemiluminescence mediated SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. This method could have potential applications in clinics for early stage tumor diagnosis.


cancer diagnosis sonodynamic chemiluminescence 


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Copyright information

© Science in China Press 2003

Authors and Affiliations

  1. 1.Institute of Laser Life ScienceSouth China Normal UniversityGuangzhouChina

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